Advertisement
Research Article

Calpain-5 Mutations Cause Autoimmune Uveitis, Retinal Neovascularization, and Photoreceptor Degeneration

  • Vinit B. Mahajan,

    Affiliation: Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States of America

    X
  • Jessica M. Skeie,

    Affiliation: Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States of America

    X
  • Alexander G. Bassuk,

    Affiliations: Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States of America, Department of Neurology, University of Iowa, Iowa City, Iowa, United States of America

    X
  • John H. Fingert,

    Affiliation: Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States of America

    X
  • Terry A. Braun,

    Affiliations: Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States of America, Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa, United States of America

    X
  • Heather T. Daggett,

    Affiliation: Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States of America

    X
  • James C. Folk,

    Affiliation: Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States of America

    X
  • Val C. Sheffield,

    Affiliations: Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States of America, Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States of America, Howard Hughes Medical Institute, Iowa City, Iowa, United States of America

    X
  • Edwin M. Stone mail

    edwin-stone@uiowa.edu

    Affiliations: Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States of America, Howard Hughes Medical Institute, Iowa City, Iowa, United States of America

    X
  • Published: October 04, 2012
  • DOI: 10.1371/journal.pgen.1003001

About the Authors

Vinit B. Mahajan, Jessica M. Skeie, John H. Fingert, Terry A. Braun, Heather T. Daggett, James C. Folk, Val C. Sheffield, Edwin M. Stone
Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States of America
Alexander G. Bassuk, Val C. Sheffield
Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States of America
Alexander G. Bassuk
Department of Neurology, University of Iowa, Iowa City, Iowa, United States of America
Terry A. Braun
Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa, United States of America
Val C. Sheffield, Edwin M. Stone
Howard Hughes Medical Institute, Iowa City, Iowa, United States of America

Corresponding Author

Email: edwin-stone@uiowa.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: VBM JMS JHF TAB VCS EMS. Performed the experiments: VBM JMS JHF HTD VCS EMS. Analyzed the data: VBM JMS AGB JHF TAB HTD JCF VCS EMS. Contributed reagents/materials/analysis tools: VBM AGB TAB VCS EMS. Wrote the paper: VBM JMS VCS EMS. Medical examination of patients and phenotype ascertainment: VBM JCF EMS.