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Research Article

The Contribution of RNA Decay Quantitative Trait Loci to Inter-Individual Variation in Steady-State Gene Expression Levels

  • Athma A. Pai mail,

    athma@uchicago.edu (AA Pai); pritch@uchicago.edu (JK Pritchard); gilad@uchicago.edu (Y Gilad)

    Affiliation: Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

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  • Carolyn E. Cain,

    Affiliation: Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

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  • Orna Mizrahi-Man,

    Affiliation: Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

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  • Sherryl De Leon,

    Affiliation: Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois, United States of America

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  • Noah Lewellen,

    Affiliation: Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois, United States of America

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  • Jean-Baptiste Veyrieras,

    Affiliations: Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America, BioMiningLabs, Lyon, France

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  • Jacob F. Degner,

    Affiliations: Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America, Committee on Genetics, Genomics, and Systems Biology, University of Chicago, Chicago, Illinois, United States of America

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  • Daniel J. Gaffney,

    Affiliations: Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois, United States of America

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  • Joseph K. Pickrell,

    Affiliation: Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

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  • Matthew Stephens,

    Affiliations: Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America, Department of Statistics, University of Chicago, Chicago, Illinois, United States of America

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  • Jonathan K. Pritchard mail,

    athma@uchicago.edu (AA Pai); pritch@uchicago.edu (JK Pritchard); gilad@uchicago.edu (Y Gilad)

    Affiliations: Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America, BioMiningLabs, Lyon, France

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  • Yoav Gilad mail

    athma@uchicago.edu (AA Pai); pritch@uchicago.edu (JK Pritchard); gilad@uchicago.edu (Y Gilad)

    Affiliation: Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

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  • Published: October 11, 2012
  • DOI: 10.1371/journal.pgen.1003000

About the Authors

Athma A. Pai, Carolyn E. Cain, Orna Mizrahi-Man, Jean-Baptiste Veyrieras, Jacob F. Degner, Daniel J. Gaffney, Joseph K. Pickrell, Matthew Stephens, Jonathan K. Pritchard, Yoav Gilad
Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
Sherryl De Leon, Noah Lewellen, Daniel J. Gaffney
Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois, United States of America
Jean-Baptiste Veyrieras, Jonathan K. Pritchard
BioMiningLabs, Lyon, France
Jacob F. Degner
Committee on Genetics, Genomics, and Systems Biology, University of Chicago, Chicago, Illinois, United States of America
Matthew Stephens
Department of Statistics, University of Chicago, Chicago, Illinois, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AA Pai, JK Pritchard, Y Gilad. Led data collection and performed experiments: AA Pai. Assisted in performing the experiments: S De Leon, N Lewellen. Collected the PolII ChIP-seq data: CE Cain. Analyzed the data: AA Pai. Assisted in analysis and contributed analysis tools: OMizrahi-Man, J-B Veyrieras, JF Degner, DJ Gaffney, JK Pickrell. Helped develop the statistical methods: M Stephens. Wrote the manuscript with input from all authors: AA Pai, JK Pritchard, Y Gilad. Jointly supervised the project: JK Pritchard, Y Gilad.