Advertisement
Research Article

The SET-Domain Protein SUVR5 Mediates H3K9me2 Deposition and Silencing at Stimulus Response Genes in a DNA Methylation–Independent Manner

  • Elena Caro,

    Affiliation: Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Hume Stroud,

    Affiliation: Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Maxim V. C. Greenberg,

    Affiliation: Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Yana V. Bernatavichute,

    Affiliation: Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Suhua Feng,

    Affiliation: Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Martin Groth,

    Affiliation: Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Ajay A. Vashisht,

    Affiliation: Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • James Wohlschlegel,

    Affiliation: Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Steve E. Jacobsen mail

    jacobsen@ucla.edu

    Affiliations: Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, California, United States of America, Howard Hughes Medical Institute, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Published: October 11, 2012
  • DOI: 10.1371/journal.pgen.1002995

About the Authors

Elena Caro, Hume Stroud, Maxim V. C. Greenberg, Yana V. Bernatavichute, Suhua Feng, Martin Groth, Steve E. Jacobsen
Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, California, United States of America
Ajay A. Vashisht, James Wohlschlegel
Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
Steve E. Jacobsen
Howard Hughes Medical Institute, University of California Los Angeles, Los Angeles, California, United States of America

Corresponding Author

Email: jacobsen@ucla.edu

Competing Interests

The Regents of the University of California have filed a provisional patent application directed at an invention related to the subject matter of this paper for which SEJ and EC are named inventors.

Author Contributions

Conceived and designed the experiments: EC HS MVCG SEJ. Performed the experiments: EC HS MVCG YVB SF MG AAV. Analyzed the data: EC HS MVCG AAV JW SEJ. Wrote the paper: EC SEJ.