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Research Article

Muscle-Specific Splicing Factors ASD-2 and SUP-12 Cooperatively Switch Alternative Pre-mRNA Processing Patterns of the ADF/Cofilin Gene in Caenorhabditis elegans

  • Genta Ohno,

    Affiliations: Laboratory of Gene Expression, Graduate School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan, Department of Functional Genomics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan, Research Fellowship for Young Scientists, Japan Society for the Promotion of Science (JSPS), Tokyo, Japan

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  • Kanako Ono,

    Affiliation: Department of Pathology, Emory University, Atlanta, Georgia, United States of America

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  • Marina Togo,

    Affiliation: Laboratory of Gene Expression, Graduate School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan

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  • Yohei Watanabe,

    Affiliation: Laboratory of Gene Expression, Graduate School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan

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  • Shoichiro Ono,

    Affiliation: Department of Pathology, Emory University, Atlanta, Georgia, United States of America

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  • Masatoshi Hagiwara,

    Affiliations: Laboratory of Gene Expression, Graduate School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan, Department of Functional Genomics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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  • Hidehito Kuroyanagi mail

    kuroyana.end@tmd.ac.jp

    Affiliations: Laboratory of Gene Expression, Graduate School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan, Department of Functional Genomics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan, Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency (JST), Kawaguchi, Saitama, Japan

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  • Published: October 11, 2012
  • DOI: 10.1371/journal.pgen.1002991

About the Authors

Genta Ohno, Marina Togo, Yohei Watanabe, Masatoshi Hagiwara, Hidehito Kuroyanagi
Laboratory of Gene Expression, Graduate School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
Genta Ohno, Masatoshi Hagiwara, Hidehito Kuroyanagi
Department of Functional Genomics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
Genta Ohno
Research Fellowship for Young Scientists, Japan Society for the Promotion of Science (JSPS), Tokyo, Japan
Kanako Ono, Shoichiro Ono
Department of Pathology, Emory University, Atlanta, Georgia, United States of America
Masatoshi Hagiwara
Graduate School of Medicine, Kyoto University, Kyoto, Japan
Hidehito Kuroyanagi
Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency (JST), Kawaguchi, Saitama, Japan

Corresponding Author

Email: kuroyana.end@tmd.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GO SO MH HK. Performed the experiments: GO KO MT YW HK. Analyzed the data: GO SO HK. Contributed reagents/materials/analysis tools: GO KO YW SO HK. Wrote the paper: GO SO MH HK.