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Research Article

Loss of Slc4a1b Chloride/Bicarbonate Exchanger Function Protects Mechanosensory Hair Cells from Aminoglycoside Damage in the Zebrafish Mutant persephone

  • Dale W. Hailey,

    Affiliations: Department of Biological Structure, University of Washington, Seattle, Washington, United States of America, Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, Washington, United States of America

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  • Brock Roberts,

    Affiliations: Department of Biological Structure, University of Washington, Seattle, Washington, United States of America, Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, Washington, United States of America

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  • Kelly N. Owens,

    Affiliations: Department of Biological Structure, University of Washington, Seattle, Washington, United States of America, Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, Washington, United States of America, Department of Otolaryngology–Head and Neck Surgery, University of Washington, Seattle, Washington, United States of America

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  • Andrew K. Stewart,

    Affiliation: Renal Division and Molecular and Vascular Medicine Unit, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

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  • Tor Linbo,

    Affiliation: Department of Biological Structure, University of Washington, Seattle, Washington, United States of America

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  • Remy Pujol,

    Affiliations: Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, Washington, United States of America, Department of Otolaryngology–Head and Neck Surgery, University of Washington, Seattle, Washington, United States of America, INSERM Unit 583, Universite de Montpellier, Institut des Neurosciences de Montpellier, Hopital St. Eloi, Montpellier, France

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  • Seth L. Alper,

    Affiliation: Renal Division and Molecular and Vascular Medicine Unit, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

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  • Edwin W. Rubel,

    Affiliations: Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, Washington, United States of America, Department of Otolaryngology–Head and Neck Surgery, University of Washington, Seattle, Washington, United States of America

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  • David W. Raible mail

    draible@u.washington.edu

    Affiliations: Department of Biological Structure, University of Washington, Seattle, Washington, United States of America, Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, Washington, United States of America

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  • Published: October 11, 2012
  • DOI: 10.1371/journal.pgen.1002971

About the Authors

Dale W. Hailey, Brock Roberts, Kelly N. Owens, Tor Linbo, David W. Raible
Department of Biological Structure, University of Washington, Seattle, Washington, United States of America
Dale W. Hailey, Brock Roberts, Kelly N. Owens, Remy Pujol, Edwin W. Rubel, David W. Raible
Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, Washington, United States of America
Kelly N. Owens, Remy Pujol, Edwin W. Rubel
Department of Otolaryngology–Head and Neck Surgery, University of Washington, Seattle, Washington, United States of America
Andrew K. Stewart, Seth L. Alper
Renal Division and Molecular and Vascular Medicine Unit, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
Remy Pujol
INSERM Unit 583, Universite de Montpellier, Institut des Neurosciences de Montpellier, Hopital St. Eloi, Montpellier, France

Corresponding Author

Email: draible@u.washington.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DWH BR KNO AKS RP SLA EWR DWR. Performed the experiments: DWH BR KNO AKS RP TL. Analyzed the data: DWH BR KNO AKS RP SLA EWR DWR. Wrote the paper: DWH KNO SLA EWR DWR.