Advertisement
Research Article

Phosphatase-Dead Myotubularin Ameliorates X-Linked Centronuclear Myopathy Phenotypes in Mice

  • Leonela Amoasii equal contributor,

    equal contributor Contributed equally to this work with: Leonela Amoasii, Dimitri L. Bertazzi

    Affiliation: Department of Translational Medecine, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U964, CNRS UMR7104, Université de Strasbourg, Collège de France, Illkirch, France

    X
  • Dimitri L. Bertazzi equal contributor,

    equal contributor Contributed equally to this work with: Leonela Amoasii, Dimitri L. Bertazzi

    Affiliation: Department of Molecular and Cellular Genetics, UMR7156, Université de Strasbourg and CNRS, Strasbourg, France

    X
  • Hélène Tronchère,

    Affiliation: INSERM, U1048 and Université Toulouse 3, I2MC, Toulouse, France

    X
  • Karim Hnia,

    Affiliation: Department of Translational Medecine, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U964, CNRS UMR7104, Université de Strasbourg, Collège de France, Illkirch, France

    X
  • Gaëtan Chicanne,

    Affiliation: INSERM, U1048 and Université Toulouse 3, I2MC, Toulouse, France

    X
  • Bruno Rinaldi,

    Affiliation: Department of Molecular and Cellular Genetics, UMR7156, Université de Strasbourg and CNRS, Strasbourg, France

    X
  • Belinda S. Cowling,

    Affiliation: Department of Translational Medecine, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U964, CNRS UMR7104, Université de Strasbourg, Collège de France, Illkirch, France

    X
  • Arnaud Ferry,

    Affiliation: UMRS974, Université Pierre et Marie Curie, Paris, France

    X
  • Bruno Klaholz,

    Affiliation: Department of Integrated Structural Biology, IGBMC, INSERM U964, CNRS UMR7104, Université de Strasbourg, Illkirch, France

    X
  • Bernard Payrastre mail,

    S.Friant@unistra.fr (SF); jocelyn@igbmc.fr (JL); bernard.payrastre@inserm.fr (BP)

    Affiliations: INSERM, U1048 and Université Toulouse 3, I2MC, Toulouse, France, CHU de Toulouse, Laboratoire d'Hématologie, Toulouse, France

    These authors were joint senior authors on this work.

    X
  • Jocelyn Laporte mail,

    S.Friant@unistra.fr (SF); jocelyn@igbmc.fr (JL); bernard.payrastre@inserm.fr (BP)

    Affiliation: Department of Translational Medecine, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U964, CNRS UMR7104, Université de Strasbourg, Collège de France, Illkirch, France

    These authors were joint senior authors on this work.

    X
  • Sylvie Friant mail

    S.Friant@unistra.fr (SF); jocelyn@igbmc.fr (JL); bernard.payrastre@inserm.fr (BP)

    Affiliation: Department of Molecular and Cellular Genetics, UMR7156, Université de Strasbourg and CNRS, Strasbourg, France

    These authors were joint senior authors on this work.

    X
  • Published: October 11, 2012
  • DOI: 10.1371/journal.pgen.1002965

About the Authors

Leonela Amoasii, Karim Hnia, Belinda S. Cowling, Jocelyn Laporte
Department of Translational Medecine, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U964, CNRS UMR7104, Université de Strasbourg, Collège de France, Illkirch, France
Dimitri L. Bertazzi, Bruno Rinaldi, Sylvie Friant
Department of Molecular and Cellular Genetics, UMR7156, Université de Strasbourg and CNRS, Strasbourg, France
Hélène Tronchère, Gaëtan Chicanne, Bernard Payrastre
INSERM, U1048 and Université Toulouse 3, I2MC, Toulouse, France
Arnaud Ferry
UMRS974, Université Pierre et Marie Curie, Paris, France
Bruno Klaholz
Department of Integrated Structural Biology, IGBMC, INSERM U964, CNRS UMR7104, Université de Strasbourg, Illkirch, France
Bernard Payrastre
CHU de Toulouse, Laboratoire d'Hématologie, Toulouse, France

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SF JL BP KH HT BSC LA DLB. Performed the experiments: LA DLB HT KH GC BR AF BK SF. Analyzed the data: LA DLB KH HT AF BK BP JL SF. Contributed reagents/materials/analysis tools: LA DLB KH HT BR GC BSC BK AF. Wrote the paper: LA DLB JL SF.