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Research Article

Tetraspanin Is Required for Generation of Reactive Oxygen Species by the Dual Oxidase System in Caenorhabditis elegans

  • Hiroki Moribe mail,

    himoribe@med.kurume-u.ac.jp

    Affiliations: Department of Biology, Kurume University School of Medicine, Kurume, Fukuoka, Japan, Department of Cell Biology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

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  • Ryouji Konakawa,

    Affiliation: Department of Cell Biology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

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  • Daisuke Koga,

    Affiliation: Division of Microscopic Anatomy and Bio-Imaging, Niigata University Graduate School of Medical and Dental Sciences, Chuo-ku, Niigata, Japan

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  • Tatsuo Ushiki,

    Affiliation: Division of Microscopic Anatomy and Bio-Imaging, Niigata University Graduate School of Medical and Dental Sciences, Chuo-ku, Niigata, Japan

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  • Kuniaki Nakamura,

    Affiliation: Department of Cell Biology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

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  • Eisuke Mekada

    Affiliation: Department of Cell Biology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

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  • Published: September 20, 2012
  • DOI: 10.1371/journal.pgen.1002957

About the Authors

Hiroki Moribe
Department of Biology, Kurume University School of Medicine, Kurume, Fukuoka, Japan
Hiroki Moribe, Ryouji Konakawa, Kuniaki Nakamura, Eisuke Mekada
Department of Cell Biology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
Daisuke Koga, Tatsuo Ushiki
Division of Microscopic Anatomy and Bio-Imaging, Niigata University Graduate School of Medical and Dental Sciences, Chuo-ku, Niigata, Japan

Corresponding Author

Email: himoribe@med.kurume-u.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HM EM. Performed the experiments: HM RK DK KN. Analyzed the data: HM. Contributed reagents/materials/analysis tools: HM RK DK TU. Wrote the paper: HM.