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Research Article

Enrichment of HP1a on Drosophila Chromosome 4 Genes Creates an Alternate Chromatin Structure Critical for Regulation in this Heterochromatic Domain

  • Nicole C. Riddle equal contributor,

    equal contributor Contributed equally to this work with: Nicole C. Riddle, Youngsook L. Jung, Tingting Gu

    Affiliation: Department of Biology, Washington University in St. Louis, St. Louis, Missouri, United States of America

    X
  • Youngsook L. Jung equal contributor,

    equal contributor Contributed equally to this work with: Nicole C. Riddle, Youngsook L. Jung, Tingting Gu

    Affiliation: Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Tingting Gu equal contributor,

    equal contributor Contributed equally to this work with: Nicole C. Riddle, Youngsook L. Jung, Tingting Gu

    Affiliation: Department of Biology, Washington University in St. Louis, St. Louis, Missouri, United States of America

    X
  • Artyom A. Alekseyenko,

    Affiliation: Division of Genetics, Department of Medicine, Brigham and Women's Hospital, and Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Dalal Asker,

    Affiliations: Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, United States of America, Food Science and Technology Department, Faculty of Agriculture, Alexandria University, Alexandria, Egypt

    X
  • Hongxing Gui,

    Affiliation: Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, United States of America

    X
  • Peter V. Kharchenko,

    Affiliation: Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Aki Minoda,

    Affiliations: Department of Molecular and Cell Biology, University of California Berkeley, California, United States of America, Department of Genome Dynamics, Lawrence Berkeley National Lab, Berkeley, California, United States of America

    X
  • Annette Plachetka,

    Affiliation: Division of Genetics, Department of Medicine, Brigham and Women's Hospital, and Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Yuri B. Schwartz,

    Affiliations: Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, United States of America, Department of Molecular Biology, Umea University, Umea, Sweden

    X
  • Michael Y. Tolstorukov,

    Affiliation: Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Mitzi I. Kuroda,

    Affiliation: Division of Genetics, Department of Medicine, Brigham and Women's Hospital, and Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Vincenzo Pirrotta,

    Affiliation: Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, United States of America

    X
  • Gary H. Karpen,

    Affiliations: Department of Molecular and Cell Biology, University of California Berkeley, California, United States of America, Department of Genome Dynamics, Lawrence Berkeley National Lab, Berkeley, California, United States of America

    X
  • Peter J. Park mail,

    peter_park@hms.harvard.edu (PJP); riddlenc@biology2.wustl.edu (SCRE)

    Affiliation: Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Sarah C. R. Elgin mail

    peter_park@hms.harvard.edu (PJP); riddlenc@biology2.wustl.edu (SCRE)

    Affiliation: Department of Biology, Washington University in St. Louis, St. Louis, Missouri, United States of America

    X
  • Published: September 20, 2012
  • DOI: 10.1371/journal.pgen.1002954

About the Authors

Nicole C. Riddle, Tingting Gu, Sarah C. R. Elgin
Department of Biology, Washington University in St. Louis, St. Louis, Missouri, United States of America
Youngsook L. Jung, Peter V. Kharchenko, Michael Y. Tolstorukov, Peter J. Park
Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America
Artyom A. Alekseyenko, Annette Plachetka, Mitzi I. Kuroda
Division of Genetics, Department of Medicine, Brigham and Women's Hospital, and Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
Dalal Asker, Hongxing Gui, Yuri B. Schwartz, Vincenzo Pirrotta
Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, United States of America
Dalal Asker
Food Science and Technology Department, Faculty of Agriculture, Alexandria University, Alexandria, Egypt
Aki Minoda, Gary H. Karpen
Department of Molecular and Cell Biology, University of California Berkeley, California, United States of America
Aki Minoda, Gary H. Karpen
Department of Genome Dynamics, Lawrence Berkeley National Lab, Berkeley, California, United States of America
Yuri B. Schwartz
Department of Molecular Biology, Umea University, Umea, Sweden

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NCR TG MIK VP GHK PJP SCRE. Performed the experiments: NCR TG AAA DA HG AM AP YBS. Analyzed the data: NCR TG YLJ. Contributed reagents/materials/analysis tools: PVK MYT. Wrote the paper: NCR YLJ TG PJP SCRE.