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Research Article

Two Distinct Repressive Mechanisms for Histone 3 Lysine 4 Methylation through Promoting 3′-End Antisense Transcription

  • Thanasis Margaritis,

    Affiliation: Molecular Cancer Research, University Medical Center Utrecht, Utrecht, The Netherlands

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  • Vincent Oreal,

    Affiliation: Marseille Cancer Research Center (CRCM), U1068 Inserm, UMR7258 CNRS, Aix-Marseille Université, Institut Paoli-Calmettes, Marseille, France

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  • Nathalie Brabers,

    Affiliation: Molecular Cancer Research, University Medical Center Utrecht, Utrecht, The Netherlands

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  • Laetitia Maestroni,

    Affiliation: Marseille Cancer Research Center (CRCM), U1068 Inserm, UMR7258 CNRS, Aix-Marseille Université, Institut Paoli-Calmettes, Marseille, France

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  • Adeline Vitaliano-Prunier,

    Affiliation: Institut Jacques Monod, Université Paris Diderot, CNRS, Paris, France

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  • Joris J. Benschop,

    Affiliation: Molecular Cancer Research, University Medical Center Utrecht, Utrecht, The Netherlands

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  • Sander van Hooff,

    Affiliation: Molecular Cancer Research, University Medical Center Utrecht, Utrecht, The Netherlands

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  • Dik van Leenen,

    Affiliation: Molecular Cancer Research, University Medical Center Utrecht, Utrecht, The Netherlands

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  • Catherine Dargemont equal contributor mail,

    equal contributor Contributed equally to this work with: Catherine Dargemont, Vincent Géli, Frank C. P. Holstege

    dargemont.catherine@ijm.univ-paris-diderot.fr (CD); geli@ifr88.cnrs-mrs.fr (VG); f.c.p.holstege@umcutrecht.nl (FCPH)

    Affiliation: Institut Jacques Monod, Université Paris Diderot, CNRS, Paris, France

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  • Vincent Géli equal contributor mail,

    equal contributor Contributed equally to this work with: Catherine Dargemont, Vincent Géli, Frank C. P. Holstege

    dargemont.catherine@ijm.univ-paris-diderot.fr (CD); geli@ifr88.cnrs-mrs.fr (VG); f.c.p.holstege@umcutrecht.nl (FCPH)

    Affiliation: Marseille Cancer Research Center (CRCM), U1068 Inserm, UMR7258 CNRS, Aix-Marseille Université, Institut Paoli-Calmettes, Marseille, France

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  • Frank C. P. Holstege equal contributor mail

    equal contributor Contributed equally to this work with: Catherine Dargemont, Vincent Géli, Frank C. P. Holstege

    dargemont.catherine@ijm.univ-paris-diderot.fr (CD); geli@ifr88.cnrs-mrs.fr (VG); f.c.p.holstege@umcutrecht.nl (FCPH)

    Affiliation: Molecular Cancer Research, University Medical Center Utrecht, Utrecht, The Netherlands

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  • Published: September 20, 2012
  • DOI: 10.1371/journal.pgen.1002952

About the Authors

Thanasis Margaritis, Nathalie Brabers, Joris J. Benschop, Sander van Hooff, Dik van Leenen, Frank C. P. Holstege
Molecular Cancer Research, University Medical Center Utrecht, Utrecht, The Netherlands
Vincent Oreal, Laetitia Maestroni, Vincent Géli
Marseille Cancer Research Center (CRCM), U1068 Inserm, UMR7258 CNRS, Aix-Marseille Université, Institut Paoli-Calmettes, Marseille, France
Adeline Vitaliano-Prunier, Catherine Dargemont
Institut Jacques Monod, Université Paris Diderot, CNRS, Paris, France

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TM CD VG FCPH. Performed the experiments: TM VO NB LM AV-P JJB DvL. Analyzed the data: TM VO NB LM AV-P JJB SvH DvL CD VG FCPH. Contributed reagents/materials/analysis tools: TM VO NB LM AV-P JJB SvH DvL CD VG FCPH. Wrote the paper: TM CD VG FCPH.