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Research Article

Functional Variants in NFKBIE and RTKN2 Involved in Activation of the NF-κB Pathway Are Associated with Rheumatoid Arthritis in Japanese

  • Keiko Myouzen,

    Affiliation: Laboratory for Autoimmune Diseases, Center for Genomic Medicine (CGM), RIKEN, Yokohama, Japan

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  • Yuta Kochi mail,

    ykochi@src.riken.jp

    Affiliations: Laboratory for Autoimmune Diseases, Center for Genomic Medicine (CGM), RIKEN, Yokohama, Japan, Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan

    X
  • Yukinori Okada,

    Affiliations: Laboratory for Autoimmune Diseases, Center for Genomic Medicine (CGM), RIKEN, Yokohama, Japan, Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan, Laboratory for Statistical Analysis, CGM, RIKEN, Yokohama, Japan

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  • Chikashi Terao,

    Affiliations: Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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  • Akari Suzuki,

    Affiliation: Laboratory for Autoimmune Diseases, Center for Genomic Medicine (CGM), RIKEN, Yokohama, Japan

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  • Katsunori Ikari,

    Affiliation: Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan

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  • Tatsuhiko Tsunoda,

    Affiliation: Laboratory for Medical Informatics, CGM, RIKEN, Yokohama, Japan

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  • Atsushi Takahashi,

    Affiliation: Laboratory for Statistical Analysis, CGM, RIKEN, Yokohama, Japan

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  • Michiaki Kubo,

    Affiliation: Laboratory for Genotyping Development, CGM, RIKEN, Yokohama, Japan

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  • Atsuo Taniguchi,

    Affiliation: Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan

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  • Fumihiko Matsuda,

    Affiliations: Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan, CREST Program, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan, Institut National de la Sant? et de la Recherche M?dicale (INSERM), Unit? U852, Kyoto University Graduate School of Medicine, Kyoto, Japan

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  • Koichiro Ohmura,

    Affiliation: Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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  • Shigeki Momohara,

    Affiliation: Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan

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  • Tsuneyo Mimori,

    Affiliation: Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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  • Hisashi Yamanaka,

    Affiliation: Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan

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  • Naoyuki Kamatani,

    Affiliation: Laboratory for International Alliance, CGM, RIKEN, Yokohama, Japan

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  • Ryo Yamada,

    Affiliation: Unit of Statistical Genetics, Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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  • Yusuke Nakamura,

    Affiliation: Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan

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  • Kazuhiko Yamamoto

    Affiliations: Laboratory for Autoimmune Diseases, Center for Genomic Medicine (CGM), RIKEN, Yokohama, Japan, Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan

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  • Published: September 13, 2012
  • DOI: 10.1371/journal.pgen.1002949

About the Authors

Keiko Myouzen, Yuta Kochi, Yukinori Okada, Akari Suzuki, Kazuhiko Yamamoto
Laboratory for Autoimmune Diseases, Center for Genomic Medicine (CGM), RIKEN, Yokohama, Japan
Yuta Kochi, Yukinori Okada, Kazuhiko Yamamoto
Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan
Yukinori Okada, Atsushi Takahashi
Laboratory for Statistical Analysis, CGM, RIKEN, Yokohama, Japan
Chikashi Terao, Fumihiko Matsuda
Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
Chikashi Terao, Koichiro Ohmura, Tsuneyo Mimori
Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Katsunori Ikari, Atsuo Taniguchi, Shigeki Momohara, Hisashi Yamanaka
Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Tatsuhiko Tsunoda
Laboratory for Medical Informatics, CGM, RIKEN, Yokohama, Japan
Michiaki Kubo
Laboratory for Genotyping Development, CGM, RIKEN, Yokohama, Japan
Fumihiko Matsuda
CREST Program, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
Fumihiko Matsuda
Institut National de la Sant? et de la Recherche M?dicale (INSERM), Unit? U852, Kyoto University Graduate School of Medicine, Kyoto, Japan
Naoyuki Kamatani
Laboratory for International Alliance, CGM, RIKEN, Yokohama, Japan
Ryo Yamada
Unit of Statistical Genetics, Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Yusuke Nakamura
Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan

Corresponding Author

Email: ykochi@src.riken.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: K Myouzen, Y Kochi, Y Okada, C Terao, K Ikari, K Ohmura, R Yamada, K Yamamoto. Performed the experiments: K Myouzen, Y Kochi, C Terao, A Suzuki, K Ikari, K Ohmura. Analyzed the data: K Myouzen, Y Kochi, Y Okada, C Terao, T Tsunoda, A Takahashi, R Yamada. Contributed reagents/materials/analysis tools: M Kubo, A Taniguchi, F Matsuda, K Ohmura, S Momohara, T Mimori, H Yamanaka, N Kamatani, Y Nakamura. Wrote the paper: K Myouzen, Y Kochi, Y Okada, C Terao, K Yamamoto.