Advertisement
Research Article

C. elegans SIRT6/7 Homolog SIR-2.4 Promotes DAF-16 Relocalization and Function during Stress

  • Wei-Chung Chiang equal contributor,

    equal contributor Contributed equally to this work with: Wei-Chung Chiang, Daniel X. Tishkoff, Bo Yang

    Affiliation: Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Daniel X. Tishkoff equal contributor,

    equal contributor Contributed equally to this work with: Wei-Chung Chiang, Daniel X. Tishkoff, Bo Yang

    Affiliation: Department of Pathology, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Bo Yang equal contributor,

    equal contributor Contributed equally to this work with: Wei-Chung Chiang, Daniel X. Tishkoff, Bo Yang

    Affiliation: Department of Pathology, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Joshua Wilson-Grady,

    Affiliation: Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Xiaokun Yu,

    Affiliation: Department of Internal Medicine, Division of Geriatric Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Travis Mazer,

    Affiliation: Department of Internal Medicine, Division of Geriatric Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Mark Eckersdorff,

    Affiliation: Department of Pathology, University of Michigan, Ann Arbor, Michigan, United States of America

    Current address: Regeneron Pharmaceuticals, Tarrytown, New York, United States of America

    X
  • Steven P. Gygi,

    Affiliation: Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • David B. Lombard mail,

    davidlom@umich.edu (DBL); aolinshu@umich.edu (A-LH)

    Affiliations: Department of Pathology, University of Michigan, Ann Arbor, Michigan, United States of America, Institute of Gerontology and the Geriatrics Center, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Ao-Lin Hsu mail

    davidlom@umich.edu (DBL); aolinshu@umich.edu (A-LH)

    Affiliations: Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Internal Medicine, Division of Geriatric Medicine, University of Michigan, Ann Arbor, Michigan, United States of America, Institute of Gerontology and the Geriatrics Center, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Published: September 13, 2012
  • DOI: 10.1371/journal.pgen.1002948

About the Authors

Wei-Chung Chiang, Ao-Lin Hsu
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America
Daniel X. Tishkoff, Bo Yang, Mark Eckersdorff, David B. Lombard
Department of Pathology, University of Michigan, Ann Arbor, Michigan, United States of America
Joshua Wilson-Grady, Steven P. Gygi
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America
Xiaokun Yu, Travis Mazer, Ao-Lin Hsu
Department of Internal Medicine, Division of Geriatric Medicine, University of Michigan, Ann Arbor, Michigan, United States of America
David B. Lombard, Ao-Lin Hsu
Institute of Gerontology and the Geriatrics Center, University of Michigan, Ann Arbor, Michigan, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: A-LH DBL. Performed the experiments: W-CC DXT BY JW-G XY TM ME A-LH. Analyzed the data: W-CC DXT BY JW-G XY SPG DBL A-LH . Wrote the paper: DBL A-LH.