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Research Article

Hominoid-Specific De Novo Protein-Coding Genes Originating from Long Non-Coding RNAs

  • Chen Xie equal contributor,

    equal contributor Contributed equally to this work with: Chen Xie, Yong E. Zhang, Jia-Yu Chen

    Affiliation: Center for Bioinformatics, State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing, China

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  • Yong E. Zhang equal contributor,

    equal contributor Contributed equally to this work with: Chen Xie, Yong E. Zhang, Jia-Yu Chen

    Affiliation: Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing, China

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  • Jia-Yu Chen equal contributor,

    equal contributor Contributed equally to this work with: Chen Xie, Yong E. Zhang, Jia-Yu Chen

    Affiliation: Institute of Molecular Medicine, Peking University, Beijing, China

    X
  • Chu-Jun Liu,

    Affiliation: Institute of Molecular Medicine, Peking University, Beijing, China

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  • Wei-Zhen Zhou,

    Affiliation: Center for Bioinformatics, State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing, China

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  • Ying Li,

    Affiliation: Institute of Molecular Medicine, Peking University, Beijing, China

    X
  • Mao Zhang,

    Affiliation: Institute of Molecular Medicine, Peking University, Beijing, China

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  • Rongli Zhang,

    Affiliation: Institute of Molecular Medicine, Peking University, Beijing, China

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  • Liping Wei mail,

    chuanyunli@pku.edu.cn (C-YL); weilp@mail.cbi.pku.edu.cn (LW)

    Affiliation: Center for Bioinformatics, State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing, China

    X
  • Chuan-Yun Li mail

    chuanyunli@pku.edu.cn (C-YL); weilp@mail.cbi.pku.edu.cn (LW)

    Affiliation: Institute of Molecular Medicine, Peking University, Beijing, China

    Current address: Laboratory of Bioinformatics and Genomic Medicine, Institute of Molecular Medicine, Peking University, Beijing, China

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  • Published: September 13, 2012
  • DOI: 10.1371/journal.pgen.1002942

About the Authors

Chen Xie, Wei-Zhen Zhou, Liping Wei
Center for Bioinformatics, State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing, China
Yong E. Zhang
Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
Jia-Yu Chen, Chu-Jun Liu, Ying Li, Mao Zhang, Rongli Zhang, Chuan-Yun Li
Institute of Molecular Medicine, Peking University, Beijing, China

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: C-YL LW YEZ. Performed the experiments: C-YL CX YEZ J-YC C-JL W-ZZ YL RZ MZ. Analyzed the data: C-YL CX YEZ J-YC C-JL W-ZZ YL RZ MZ. Contributed reagents/materials/analysis tools: C-YL YEZ RZ. Wrote the paper: C-YL LW YEZ.