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Research Article

Reduced Prostasin (CAP1/PRSS8) Activity Eliminates HAI-1 and HAI-2 Deficiency–Associated Developmental Defects by Preventing Matriptase Activation

  • Roman Szabo,

    Affiliation: Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Katiuchia Uzzun Sales,

    Affiliation: Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Peter Kosa,

    Affiliation: Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Natalia A. Shylo,

    Affiliation: Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Sine Godiksen,

    Affiliations: Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America, Department of Cellular and Molecular Medicine, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark, Department of Biology, Faculty of Science, University of Copenhagen, Copenhagen, Denmark

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  • Karina K. Hansen,

    Affiliation: Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Stine Friis,

    Affiliation: Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America

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  • J. Silvio Gutkind,

    Affiliation: Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Lotte K. Vogel,

    Affiliation: Department of Cellular and Molecular Medicine, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark

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  • Edith Hummler,

    Affiliation: Pharmacology and Toxicology Department, University de Lausanne, Lausanne, Switzerland

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  • Eric Camerer,

    Affiliations: INSERM U970, Paris Cardiovascular Research Centre, Paris, France, Université Paris-Descartes, Paris, France

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  • Thomas H. Bugge mail

    thomas.bugge@nih.gov

    Affiliation: Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Published: August 30, 2012
  • DOI: 10.1371/journal.pgen.1002937

About the Authors

Roman Szabo, Katiuchia Uzzun Sales, Peter Kosa, Natalia A. Shylo, Sine Godiksen, Karina K. Hansen, Stine Friis, J. Silvio Gutkind, Thomas H. Bugge
Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America
Sine Godiksen, Lotte K. Vogel
Department of Cellular and Molecular Medicine, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark
Sine Godiksen
Department of Biology, Faculty of Science, University of Copenhagen, Copenhagen, Denmark
Edith Hummler
Pharmacology and Toxicology Department, University de Lausanne, Lausanne, Switzerland
Eric Camerer
INSERM U970, Paris Cardiovascular Research Centre, Paris, France
Eric Camerer
Université Paris-Descartes, Paris, France

Corresponding Author

Email: thomas.bugge@nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RS THB JSG. Performed the experiments: RS KUS PK NAS SG EC KKH SF. Analyzed the data: RS KUS PK NAS EC THB KKH. Contributed reagents/materials/analysis tools: SG LKV EH. Wrote the paper: RS THB.