Advertisement
Research Article

Combining Comparative Proteomics and Molecular Genetics Uncovers Regulators of Synaptic and Axonal Stability and Degeneration In Vivo

  • Thomas M. Wishart,

    Affiliations: Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom, Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, United Kingdom, Division of Neurobiology, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom

    X
  • Timothy M. Rooney,

    Affiliation: Department of Neurobiology, Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

    X
  • Douglas J. Lamont,

    Affiliation: FingerPrints Proteomics Facility, College of Life Sciences, University of Dundee, Dundee, United Kingdom

    X
  • Ann K. Wright,

    Affiliations: Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom, Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, United Kingdom

    X
  • A. Jennifer Morton,

    Affiliation: Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom

    X
  • Mandy Jackson,

    Affiliations: Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom, Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, United Kingdom

    X
  • Marc R. Freeman,

    Affiliation: Department of Neurobiology, Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

    X
  • Thomas H. Gillingwater mail

    T.Gillingwater@ed.ac.uk

    Affiliations: Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom, Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, United Kingdom

    X
  • Published: August 30, 2012
  • DOI: 10.1371/journal.pgen.1002936

About the Authors

Thomas M. Wishart, Ann K. Wright, Mandy Jackson, Thomas H. Gillingwater
Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom
Thomas M. Wishart, Ann K. Wright, Mandy Jackson, Thomas H. Gillingwater
Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, United Kingdom
Thomas M. Wishart
Division of Neurobiology, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom
Timothy M. Rooney, Marc R. Freeman
Department of Neurobiology, Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
Douglas J. Lamont
FingerPrints Proteomics Facility, College of Life Sciences, University of Dundee, Dundee, United Kingdom
A. Jennifer Morton
Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom

Corresponding Author

Email: T.Gillingwater@ed.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TMW MRF THG. Performed the experiments: TMW TMR DJL AKW THG. Analyzed the data: TMW TMR MRF THG. Contributed reagents/materials/analysis tools: AJM MJ. Wrote the paper: TMW TMR MRF THG.