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Research Article

Citrullination of Histone H3 Interferes with HP1-Mediated Transcriptional Repression

  • Priyanka Sharma,

    Affiliation: Institut Pasteur, Département de Biologie du Développement, CNRS URA2578, Unité de Régulation Epigénétique, Paris, France

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  • Saliha Azebi,

    Affiliation: Institut Pasteur, Département de Biologie du Développement, CNRS URA2578, Unité de Régulation Epigénétique, Paris, France

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  • Patrick England,

    Affiliation: Institut Pasteur, Département de Biologie Structurale et Chimie, CNRS UMR3528, Plate-Forme de Biophysique des Macromolécules et de Leurs Interactions, Paris, France

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  • Tove Christensen,

    Affiliation: Department of Biomedicine, Aarhus University, Aarhus, Denmark

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  • Anné Møller-Larsen,

    Affiliation: Department of Biomedicine, Aarhus University, Aarhus, Denmark

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  • Thor Petersen,

    Affiliation: Department of Neurology, Aarhus University Hospital, Aarhus, Denmark

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  • Eric Batsché,

    Affiliation: Institut Pasteur, Département de Biologie du Développement, CNRS URA2578, Unité de Régulation Epigénétique, Paris, France

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  • Christian Muchardt mail

    muchardt@pasteur.fr

    Affiliation: Institut Pasteur, Département de Biologie du Développement, CNRS URA2578, Unité de Régulation Epigénétique, Paris, France

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  • Published: September 13, 2012
  • DOI: 10.1371/journal.pgen.1002934

About the Authors

Priyanka Sharma, Saliha Azebi, Eric Batsché, Christian Muchardt
Institut Pasteur, Département de Biologie du Développement, CNRS URA2578, Unité de Régulation Epigénétique, Paris, France
Patrick England
Institut Pasteur, Département de Biologie Structurale et Chimie, CNRS UMR3528, Plate-Forme de Biophysique des Macromolécules et de Leurs Interactions, Paris, France
Tove Christensen, Anné Møller-Larsen
Department of Biomedicine, Aarhus University, Aarhus, Denmark
Thor Petersen
Department of Neurology, Aarhus University Hospital, Aarhus, Denmark

Corresponding Author

Email: muchardt@pasteur.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CM PS. Performed the experiments: PS SA PE. Analyzed the data: PS CM PE EB TC AM-L TP. Contributed reagents/materials/analysis tools: TC AM-L TP. Wrote the paper: CM PS SA TC PE EB AM-L TP. Conceived the idea: CM. Designed the experiments: CM PS. Performed the molecular biology and cell biology experiments in cell culture: PS. Analysed the data for biology and cell biology experiments: CM PS. Performed the MS patients experiments: PS. Analyzed the data for MS patient experiments: PS CM EB TC AM-L TP. Generated PADI4 stable cell line also performed and analysed the Western blot and some qPCRs: SA. Performed and analyzed the Surface Plasmon experimental data: PE and PS. Contributed to acquiring MS patient samples to perform the experiments: TC AM-L TP. Wrote the manuscript: CM PS. Corrected and approved the manuscript: SA TC PE EB AM-L TP.