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Research Article

H4K20me1 Contributes to Downregulation of X-Linked Genes for C. elegans Dosage Compensation

  • Anne Vielle equal contributor,

    equal contributor Contributed equally to this work with: Anne Vielle, Jackie Lang

    Affiliation: The Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge, United Kingdom

    X
  • Jackie Lang equal contributor,

    equal contributor Contributed equally to this work with: Anne Vielle, Jackie Lang

    Affiliation: Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America

    X
  • Yan Dong,

    Affiliation: The Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge, United Kingdom

    X
  • Sevinc Ercan,

    Affiliations: Department of Biology, Carolina Center for the Genome Sciences, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America

    X
  • Chitra Kotwaliwale,

    Affiliations: Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences (QB3), University of California Berkeley, Berkeley, California, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

    X
  • Andreas Rechtsteiner,

    Affiliation: Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America

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  • Alex Appert,

    Affiliation: The Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge, United Kingdom

    X
  • Q. Brent Chen,

    Affiliation: Department of Biology, Carolina Center for the Genome Sciences, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Andrea Dose,

    Affiliations: Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences (QB3), University of California Berkeley, Berkeley, California, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

    X
  • Thea Egelhofer,

    Affiliation: Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America

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  • Hiroshi Kimura,

    Affiliation: Graduate School for Frontier Biosciences, Osaka University, Osaka, Japan

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  • Przemyslaw Stempor,

    Affiliation: The Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge, United Kingdom

    X
  • Abby Dernburg,

    Affiliations: Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences (QB3), University of California Berkeley, Berkeley, California, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

    X
  • Jason D. Lieb,

    Affiliation: Department of Biology, Carolina Center for the Genome Sciences, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Susan Strome,

    Affiliation: Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America

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  • Julie Ahringer mail

    ja219@cam.ac.uk

    Affiliation: The Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge, United Kingdom

    X
  • Published: September 13, 2012
  • DOI: 10.1371/journal.pgen.1002933

About the Authors

Anne Vielle, Yan Dong, Alex Appert, Przemyslaw Stempor, Julie Ahringer
The Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge, United Kingdom
Jackie Lang, Andreas Rechtsteiner, Thea Egelhofer, Susan Strome
Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America
Sevinc Ercan, Q. Brent Chen, Jason D. Lieb
Department of Biology, Carolina Center for the Genome Sciences, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Sevinc Ercan
Center for Genomics and Systems Biology, New York University, New York, New York, United States of America
Chitra Kotwaliwale, Andrea Dose, Abby Dernburg
Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences (QB3), University of California Berkeley, Berkeley, California, United States of America
Chitra Kotwaliwale, Andrea Dose, Abby Dernburg
Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America
Hiroshi Kimura
Graduate School for Frontier Biosciences, Osaka University, Osaka, Japan

Corresponding Author

Email: ja219@cam.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: J Ahringer, S Strome, S Ercan, C Kotwaliwale, A Dernburg, JD Lieb. Performed the experiments: A Vielle, J Lang, Y Dong, S Ercan, C Kotwaliwale, A Rechtsteiner, QB Chen, A Dose, T Egelhofer. Analyzed the data: A Vielle, J Lang, Y Dong, S Ercan, C Kotwaliwale, A Rechtsteiner, P Stempor, S Strome, J Ahringer. Contributed reagents/materials/analysis tools: H Kimura. Wrote the manuscript: J Ahringer, S Strome, S Ercan, C Kotwaliwale.