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Research Article

Cadm1 Is a Metastasis Susceptibility Gene That Suppresses Metastasis by Modifying Tumor Interaction with the Cell-Mediated Immunity

  • Farhoud Faraji,

    Affiliations: Metastasis Susceptibility Section, Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America, School of Medicine, Saint Louis University, St. Louis, Missouri, United States of America, Howard Hughes Medical Institute–National Institutes of Health Research Scholars Program, Chevy Chase, Maryland, United States of America

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  • Yanli Pang,

    Affiliation: Tumor Microenvironment Section, Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Renard C. Walker,

    Affiliation: Metastasis Susceptibility Section, Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Rosan Nieves Borges,

    Affiliation: Metastasis Susceptibility Section, Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Li Yang,

    Affiliation: Tumor Microenvironment Section, Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Kent W. Hunter mail

    hunterk@mail.nih.gov

    Affiliation: Metastasis Susceptibility Section, Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Published: September 20, 2012
  • DOI: 10.1371/journal.pgen.1002926

About the Authors

Farhoud Faraji, Renard C. Walker, Rosan Nieves Borges, Kent W. Hunter
Metastasis Susceptibility Section, Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Farhoud Faraji
School of Medicine, Saint Louis University, St. Louis, Missouri, United States of America
Farhoud Faraji
Howard Hughes Medical Institute–National Institutes of Health Research Scholars Program, Chevy Chase, Maryland, United States of America
Yanli Pang, Li Yang
Tumor Microenvironment Section, Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Corresponding Author

Email: hunterk@mail.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FF KWH LY. Performed the experiments: FF YP RNB RCW. Analyzed the data: KWH FF LY YP. Wrote the paper: FF KWH.