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Research Article

Genome-Wide Association Study for Serum Complement C3 and C4 Levels in Healthy Chinese Subjects

  • Xiaobo Yang equal contributor,

    equal contributor Contributed equally to this work with: Xiaobo Yang, Jielin Sun, Yong Gao, Aihua Tan, Haiying Zhang, Yanling Hu, Junjie Feng, Xue Qin

    Affiliations: Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China, Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China

    X
  • Jielin Sun equal contributor,

    equal contributor Contributed equally to this work with: Xiaobo Yang, Jielin Sun, Yong Gao, Aihua Tan, Haiying Zhang, Yanling Hu, Junjie Feng, Xue Qin

    Affiliation: Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

    X
  • Yong Gao equal contributor,

    equal contributor Contributed equally to this work with: Xiaobo Yang, Jielin Sun, Yong Gao, Aihua Tan, Haiying Zhang, Yanling Hu, Junjie Feng, Xue Qin

    Affiliations: Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China, Fudan-VARI Center for Genetic Epidemiology, School of Life Sciences, Fudan University, Shanghai, China

    X
  • Aihua Tan equal contributor,

    equal contributor Contributed equally to this work with: Xiaobo Yang, Jielin Sun, Yong Gao, Aihua Tan, Haiying Zhang, Yanling Hu, Junjie Feng, Xue Qin

    Affiliation: Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China

    X
  • Haiying Zhang equal contributor,

    equal contributor Contributed equally to this work with: Xiaobo Yang, Jielin Sun, Yong Gao, Aihua Tan, Haiying Zhang, Yanling Hu, Junjie Feng, Xue Qin

    Affiliations: Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China, Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China

    X
  • Yanling Hu equal contributor,

    equal contributor Contributed equally to this work with: Xiaobo Yang, Jielin Sun, Yong Gao, Aihua Tan, Haiying Zhang, Yanling Hu, Junjie Feng, Xue Qin

    Affiliations: Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China, Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, China

    X
  • Junjie Feng equal contributor,

    equal contributor Contributed equally to this work with: Xiaobo Yang, Jielin Sun, Yong Gao, Aihua Tan, Haiying Zhang, Yanling Hu, Junjie Feng, Xue Qin

    Affiliation: Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

    X
  • Xue Qin equal contributor,

    equal contributor Contributed equally to this work with: Xiaobo Yang, Jielin Sun, Yong Gao, Aihua Tan, Haiying Zhang, Yanling Hu, Junjie Feng, Xue Qin

    Affiliation: Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China

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  • Sha Tao,

    Affiliation: Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Zhuo Chen,

    Affiliation: Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

    X
  • Seong-Tae Kim,

    Affiliation: Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

    X
  • Tao Peng,

    Affiliations: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China, Laboratory of Genomic Diversity, National Cancer Institute, National Institutes of Health, Frederick, Maryland, United States of America

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  • Ming Liao,

    Affiliation: Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China

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  • Xiaoling Lin,

    Affiliation: Fudan-VARI Center for Genetic Epidemiology, School of Life Sciences, Fudan University, Shanghai, China

    X
  • Zengfeng Zhang,

    Affiliation: Department of Microbiology, School of Preclinical Medicine, Guangxi Medical University, Nanning, Guangxi, China

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  • Minzhong Tang,

    Affiliation: College of Life Science and Bioengineering, Beijing University of Technology, Beijing, China

    X
  • Li Li,

    Affiliation: Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, China

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  • Linjian Mo,

    Affiliation: Institute of Urology and Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China

    X
  • Zhengjia Liang,

    Affiliation: Medical Examination Center, Fangchenggang First People's Hospital, Fangchenggang, Guangxi, China

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  • Deyi Shi,

    Affiliation: Medical Examination Center, Fangchenggang First People's Hospital, Fangchenggang, Guangxi, China

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  • Zhang Huang,

    Affiliation: Medical Examination Center, Fangchenggang First People's Hospital, Fangchenggang, Guangxi, China

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  • Xianghua Huang,

    Affiliation: Medical Examination Center, Guigang People's Hospital, Guigang, Guangxi, China

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  • Ming Liu,

    Affiliation: Medical Examination Center, Yulin First People's Hospital, Yulin, Guangxi, China

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  • Qian Liu,

    Affiliation: Institute of Cardiovascular Diseases, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China

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  • Shijun Zhang,

    Affiliation: Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China

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  • Jeffrey M. Trent,

    Affiliation: Center for Genetic Epidemiology, Van Andel Research Institute, Grand Rapids, Michigan, United States of America

    X
  • S. Lilly Zheng,

    Affiliation: Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Jianfeng Xu,

    Affiliations: Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America, Fudan-VARI Center for Genetic Epidemiology, School of Life Sciences, Fudan University, Shanghai, China, Center for Genetic Epidemiology, Van Andel Research Institute, Grand Rapids, Michigan, United States of America, Fudan University Institute of Urology, Huashan Hospital, Fudan University, Shanghai, China

    X
  • Zengnan Mo mail

    zengnanmo@hotmail.com

    Affiliations: Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China, Institute of Urology and Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China

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  • Published: September 13, 2012
  • DOI: 10.1371/journal.pgen.1002916

About the Authors

Xiaobo Yang, Haiying Zhang
Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China
Xiaobo Yang, Yong Gao, Aihua Tan, Haiying Zhang, Yanling Hu, Ming Liao, Shijun Zhang, Zengnan Mo
Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China
Jielin Sun, Junjie Feng, Sha Tao, Zhuo Chen, Seong-Tae Kim, S. Lilly Zheng, Jianfeng Xu
Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America
Yong Gao, Xiaoling Lin, Jianfeng Xu
Fudan-VARI Center for Genetic Epidemiology, School of Life Sciences, Fudan University, Shanghai, China
Yanling Hu, Li Li
Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, China
Xue Qin
Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China
Tao Peng
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China
Tao Peng
Laboratory of Genomic Diversity, National Cancer Institute, National Institutes of Health, Frederick, Maryland, United States of America
Zengfeng Zhang
Department of Microbiology, School of Preclinical Medicine, Guangxi Medical University, Nanning, Guangxi, China
Minzhong Tang
College of Life Science and Bioengineering, Beijing University of Technology, Beijing, China
Linjian Mo, Zengnan Mo
Institute of Urology and Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China
Zhengjia Liang, Deyi Shi, Zhang Huang
Medical Examination Center, Fangchenggang First People's Hospital, Fangchenggang, Guangxi, China
Xianghua Huang
Medical Examination Center, Guigang People's Hospital, Guigang, Guangxi, China
Ming Liu
Medical Examination Center, Yulin First People's Hospital, Yulin, Guangxi, China
Qian Liu
Institute of Cardiovascular Diseases, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China
Jeffrey M. Trent, Jianfeng Xu
Center for Genetic Epidemiology, Van Andel Research Institute, Grand Rapids, Michigan, United States of America
Jianfeng Xu
Fudan University Institute of Urology, Huashan Hospital, Fudan University, Shanghai, China

Corresponding Author

Email: zengnanmo@hotmail.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: Zengnan Mo, Jianfeng Xu. Performed the experiments: Yanling Hu, Yong Gao, Aihua Tan, Linjian Mo, Xiaoling Lin, S. Lilly Zheng. Analyzed the data: Jielin Sun, Junjie Feng, Sha Tao, Seong-Tae Kim, Zhuo Chen, Ming Liao, Minzhong Tang. Contributed reagents/materials/analysis tools: Xue Qin, Tao Peng, Li Li, S. Lilly Zheng, Zengnan Mo. Wrote the paper: Xiaobo Yang, Jielin Sun. Sample collection and preparation: Xiaobo Yang, Yong Gao, Aihua Tan, Haiying Zhang, Zhengjia Liang, Deyi Shi, Zhang Huang, Xianghua Huang, Ming Liu, Qian Liu, Shijun Zhang. Review and revision of the manuscript: Xiaobo Yang, Jielin Sun, Junjie Feng, Jianfeng Xu, Zengnan Mo. Intellectual input: Zengfeng Zhang, Jeffrey M Trent.