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Research Article

Novel Loci for Metabolic Networks and Multi-Tissue Expression Studies Reveal Genes for Atherosclerosis

  • Michael Inouye mail,

    minouye@unimelb.edu.au

    Affiliations: Medical Systems Biology, Departments of Pathology and of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia, Immunology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia

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  • Samuli Ripatti,

    Affiliations: Institute of Molecular Medicine (FIMM), University of Helsinki, Helsinki, Finland, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland, Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Johannes Kettunen,

    Affiliations: Institute of Molecular Medicine (FIMM), University of Helsinki, Helsinki, Finland, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

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  • Leo-Pekka Lyytikäinen,

    Affiliation: Department of Clinical Chemistry, Fimlab Laboratories, Tampere University Hospital and University of Tampere School of Medicine, Tampere, Finland

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  • Niku Oksala,

    Affiliations: Department of Clinical Chemistry, Fimlab Laboratories, Tampere University Hospital and University of Tampere School of Medicine, Tampere, Finland, Division of Vascular Surgery, Department of Surgery, Tampere University Hospital, Tampere, Finland

    X
  • Pirkka-Pekka Laurila,

    Affiliations: Institute of Molecular Medicine (FIMM), University of Helsinki, Helsinki, Finland, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland, Department of Medical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

    X
  • Antti J. Kangas,

    Affiliation: Computational Medicine, Institute of Clinical Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland

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  • Pasi Soininen,

    Affiliations: Computational Medicine, Institute of Clinical Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland, NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland

    X
  • Markku J. Savolainen,

    Affiliations: Computational Medicine, Institute of Clinical Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland, Biocenter Oulu, University of Oulu, Oulu, Finland, Department of Internal Medicine, Clinical Research Center, University of Oulu, Oulu, Finland

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  • Jorma Viikari,

    Affiliation: Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland

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  • Mika Kähönen,

    Affiliation: Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland

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  • Markus Perola,

    Affiliation: Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

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  • Veikko Salomaa,

    Affiliation: Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

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  • Olli Raitakari,

    Affiliation: Research Centre of Applied and Preventive Cardiovascular Medicine and Department of Clinical Physiology, University of Turku and Turku University Hospital, Turku, Finland

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  • Terho Lehtimäki,

    Affiliation: Department of Clinical Chemistry, Fimlab Laboratories, Tampere University Hospital and University of Tampere School of Medicine, Tampere, Finland

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  • Marja-Riitta Taskinen,

    Affiliation: Department of Medicine, University of Helsinki, Helsinki, Finland

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  • Marjo-Riitta Järvelin,

    Affiliations: Biocenter Oulu, University of Oulu, Oulu, Finland, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom, Department of Public Health Science and General Practice, University of Oulu, Oulu, Finland

    X
  • Mika Ala-Korpela,

    Affiliations: Computational Medicine, Institute of Clinical Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland, NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, Department of Internal Medicine, Clinical Research Center, University of Oulu, Oulu, Finland, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom

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  • Aarno Palotie,

    Affiliations: Institute of Molecular Medicine (FIMM), University of Helsinki, Helsinki, Finland, Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom, Department of Medical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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  • Paul I. W. de Bakker

    Affiliations: Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Epidemiology, University Medical Center Utrecht, Utrecht, The Netherlands

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  • Published: August 16, 2012
  • DOI: 10.1371/journal.pgen.1002907

About the Authors

Michael Inouye
Medical Systems Biology, Departments of Pathology and of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia
Michael Inouye
Immunology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Samuli Ripatti, Johannes Kettunen, Pirkka-Pekka Laurila, Aarno Palotie
Institute of Molecular Medicine (FIMM), University of Helsinki, Helsinki, Finland
Samuli Ripatti, Johannes Kettunen, Pirkka-Pekka Laurila, Markus Perola, Veikko Salomaa
Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
Samuli Ripatti, Aarno Palotie
Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
Leo-Pekka Lyytikäinen, Niku Oksala, Terho Lehtimäki
Department of Clinical Chemistry, Fimlab Laboratories, Tampere University Hospital and University of Tampere School of Medicine, Tampere, Finland
Niku Oksala
Division of Vascular Surgery, Department of Surgery, Tampere University Hospital, Tampere, Finland
Pirkka-Pekka Laurila, Aarno Palotie
Department of Medical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Antti J. Kangas, Pasi Soininen, Markku J. Savolainen, Mika Ala-Korpela
Computational Medicine, Institute of Clinical Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland
Pasi Soininen, Mika Ala-Korpela
NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland
Markku J. Savolainen, Marjo-Riitta Järvelin
Biocenter Oulu, University of Oulu, Oulu, Finland
Markku J. Savolainen, Mika Ala-Korpela
Department of Internal Medicine, Clinical Research Center, University of Oulu, Oulu, Finland
Jorma Viikari
Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland
Mika Kähönen
Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland
Olli Raitakari
Research Centre of Applied and Preventive Cardiovascular Medicine and Department of Clinical Physiology, University of Turku and Turku University Hospital, Turku, Finland
Marja-Riitta Taskinen
Department of Medicine, University of Helsinki, Helsinki, Finland
Marjo-Riitta Järvelin, Mika Ala-Korpela
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
Marjo-Riitta Järvelin
Department of Public Health Science and General Practice, University of Oulu, Oulu, Finland
Aarno Palotie, Paul I. W. de Bakker
Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
Paul I. W. de Bakker
Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Paul I. W. de Bakker
Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
Paul I. W. de Bakker
Department of Epidemiology, University Medical Center Utrecht, Utrecht, The Netherlands

Corresponding Author

Email: minouye@unimelb.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MI PIWdB. Performed the experiments: NO AJK PS. Analyzed the data: MI SR JK L-PL P-PL PIWdB. Contributed reagents/materials/analysis tools: JK JV MK MP VS OR TL M-RJ MA-K AP MJS. Wrote the paper: MI SR M-RT AP PIWdB.