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Research Article

Variation in Genes Related to Cochlear Biology Is Strongly Associated with Adult-Onset Deafness in Border Collies

  • Jennifer S. Yokoyama equal contributor,

    equal contributor Contributed equally to this work with: Jennifer S. Yokoyama, Ernest T. Lam

    Affiliation: Department of Psychiatry and Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America

    X
  • Ernest T. Lam equal contributor,

    equal contributor Contributed equally to this work with: Jennifer S. Yokoyama, Ernest T. Lam

    Affiliation: Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America

    X
  • Alison L. Ruhe,

    Affiliations: Neurogenomics Division, The Translational Genomics Research Institute, Phoenix, Arizona, United States of America, Veterinary Genetics Laboratory, University of California Davis, Davis, California, United States of America

    X
  • Carolyn A. Erdman,

    Affiliation: Department of Psychiatry and Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America

    X
  • Kathryn R. Robertson,

    Affiliation: Veterinary Genetics Laboratory, University of California Davis, Davis, California, United States of America

    X
  • Aubrey A. Webb,

    Affiliations: CullenWebb Animal Neurology and Ophthalmology Centre, Riverview, New Brunswick, Canada, Department of Clinical Neuroscience, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada

    X
  • D. Colette Williams,

    Affiliation: School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

    X
  • Melanie L. Chang,

    Affiliation: Department of Anthropology, University of Oregon, Eugene, Oregon, United States of America

    X
  • Marjo K. Hytönen,

    Affiliation: Department of Veterinary Biosciences and Research Programs Unit, Molecular Medicine, University of Helsinki and Folkhälsan Research Center, Helsinki, Finland

    X
  • Hannes Lohi,

    Affiliation: Department of Veterinary Biosciences and Research Programs Unit, Molecular Medicine, University of Helsinki and Folkhälsan Research Center, Helsinki, Finland

    X
  • Steven P. Hamilton,

    Affiliation: Department of Psychiatry and Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America

    X
  • Mark W. Neff mail

    mark.neff@vai.org

    Affiliations: Neurogenomics Division, The Translational Genomics Research Institute, Phoenix, Arizona, United States of America, The Van Andel Research Institute, Grand Rapids, Michigan, United States of America

    X
  • Published: September 13, 2012
  • DOI: 10.1371/journal.pgen.1002898

About the Authors

Jennifer S. Yokoyama, Carolyn A. Erdman, Steven P. Hamilton
Department of Psychiatry and Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America
Ernest T. Lam
Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America
Alison L. Ruhe, Mark W. Neff
Neurogenomics Division, The Translational Genomics Research Institute, Phoenix, Arizona, United States of America
Alison L. Ruhe, Kathryn R. Robertson
Veterinary Genetics Laboratory, University of California Davis, Davis, California, United States of America
Aubrey A. Webb
CullenWebb Animal Neurology and Ophthalmology Centre, Riverview, New Brunswick, Canada
Aubrey A. Webb
Department of Clinical Neuroscience, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
D. Colette Williams
School of Veterinary Medicine, University of California Davis, Davis, California, United States of America
Melanie L. Chang
Department of Anthropology, University of Oregon, Eugene, Oregon, United States of America
Marjo K. Hytönen, Hannes Lohi
Department of Veterinary Biosciences and Research Programs Unit, Molecular Medicine, University of Helsinki and Folkhälsan Research Center, Helsinki, Finland
Mark W. Neff
The Van Andel Research Institute, Grand Rapids, Michigan, United States of America

Corresponding Author

Email: mark.neff@vai.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JSY ETL SPH MWN. Performed the experiments: JSY ETL ALR CAE KRR MKH. Analyzed the data: JSY ETL. Contributed reagents/materials/analysis tools: JSY ETL ALR CAE KRR AAW DCW MLC MKH HL SPH MWN. Wrote the paper: JSY ETL CAE AAW MLC SPH MWN. Critical reading and discussion of manuscript: AAW DCW HL ALR.