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Research Article

Identification of Human Proteins That Modify Misfolding and Proteotoxicity of Pathogenic Ataxin-1

  • Spyros Petrakis equal contributor,

    equal contributor Contributed equally to this work with: Spyros Petrakis, Tamás Raskó, Jenny Russ, Ralf P. Friedrich, Martin Stroedicke

    Affiliation: Neuroproteomics, Max Delbrueck Center for Molecular Medicine, Berlin, Germany

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  • Tamás Raskó equal contributor,

    equal contributor Contributed equally to this work with: Spyros Petrakis, Tamás Raskó, Jenny Russ, Ralf P. Friedrich, Martin Stroedicke

    Affiliation: Neuroproteomics, Max Delbrueck Center for Molecular Medicine, Berlin, Germany

    X
  • Jenny Russ equal contributor,

    equal contributor Contributed equally to this work with: Spyros Petrakis, Tamás Raskó, Jenny Russ, Ralf P. Friedrich, Martin Stroedicke

    Affiliation: Neuroproteomics, Max Delbrueck Center for Molecular Medicine, Berlin, Germany

    X
  • Ralf P. Friedrich equal contributor,

    equal contributor Contributed equally to this work with: Spyros Petrakis, Tamás Raskó, Jenny Russ, Ralf P. Friedrich, Martin Stroedicke

    Affiliation: Neuroproteomics, Max Delbrueck Center for Molecular Medicine, Berlin, Germany

    X
  • Martin Stroedicke equal contributor,

    equal contributor Contributed equally to this work with: Spyros Petrakis, Tamás Raskó, Jenny Russ, Ralf P. Friedrich, Martin Stroedicke

    Affiliation: Neuroproteomics, Max Delbrueck Center for Molecular Medicine, Berlin, Germany

    X
  • Sean-Patrick Riechers,

    Affiliation: Neuroproteomics, Max Delbrueck Center for Molecular Medicine, Berlin, Germany

    X
  • Katja Muehlenberg,

    Affiliation: Neuroproteomics, Max Delbrueck Center for Molecular Medicine, Berlin, Germany

    X
  • Angeli Möller,

    Affiliation: Neuroproteomics, Max Delbrueck Center for Molecular Medicine, Berlin, Germany

    X
  • Anita Reinhardt,

    Affiliation: Unité BFA (EAC 7059), Université Paris Diderot-Paris7/CNRS, Paris, France

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  • Arunachalam Vinayagam,

    Affiliation: Neuroproteomics, Max Delbrueck Center for Molecular Medicine, Berlin, Germany

    X
  • Martin H. Schaefer,

    Affiliation: Computational Biology and Data Mining, Max Delbrueck Center for Molecular Medicine, Berlin, Germany

    X
  • Michael Boutros,

    Affiliation: Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany

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  • Hervé Tricoire,

    Affiliation: Unité BFA (EAC 7059), Université Paris Diderot-Paris7/CNRS, Paris, France

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  • Miguel A. Andrade-Navarro,

    Affiliation: Computational Biology and Data Mining, Max Delbrueck Center for Molecular Medicine, Berlin, Germany

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  • Erich E. Wanker mail

    ewanker@mdc-berlin.de

    Affiliation: Neuroproteomics, Max Delbrueck Center for Molecular Medicine, Berlin, Germany

    X
  • Published: August 16, 2012
  • DOI: 10.1371/journal.pgen.1002897

About the Authors

Spyros Petrakis, Tamás Raskó, Jenny Russ, Ralf P. Friedrich, Martin Stroedicke, Sean-Patrick Riechers, Katja Muehlenberg, Angeli Möller, Arunachalam Vinayagam, Erich E. Wanker
Neuroproteomics, Max Delbrueck Center for Molecular Medicine, Berlin, Germany
Anita Reinhardt, Hervé Tricoire
Unité BFA (EAC 7059), Université Paris Diderot-Paris7/CNRS, Paris, France
Martin H. Schaefer, Miguel A. Andrade-Navarro
Computational Biology and Data Mining, Max Delbrueck Center for Molecular Medicine, Berlin, Germany
Michael Boutros
Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany

Corresponding Author

Email: ewanker@mdc-berlin.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SP TR MB RPF HT MAA-N EEW. Performed the experiments: SP TR JR S-PR RPF AM KM AR. Analyzed the data: JR AV MHS SP TR S-PR RPF EEW MS. Wrote the paper: EEW. Designed the study: EEW. Edited the manuscript: MS AM S-PR JR SP RPF TR MAA-N.