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Research Article

Experimental Relocation of the Mitochondrial ATP9 Gene to the Nucleus Reveals Forces Underlying Mitochondrial Genome Evolution

  • Maïlis Bietenhader equal contributor,

    equal contributor Contributed equally to this work with: Maïlis Bietenhader, Alexandre Martos, Emmanuel Tetaud, Raeka S. Aiyar

    Affiliations: Université Bordeaux, IBGC, UMR5095 CNRS, Bordeaux, France, CNRS, IBGC, UMR5095 CNRS, Bordeaux, France

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  • Alexandre Martos equal contributor,

    equal contributor Contributed equally to this work with: Maïlis Bietenhader, Alexandre Martos, Emmanuel Tetaud, Raeka S. Aiyar

    Affiliations: Université Bordeaux, IBGC, UMR5095 CNRS, Bordeaux, France, CNRS, IBGC, UMR5095 CNRS, Bordeaux, France

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  • Emmanuel Tetaud equal contributor,

    equal contributor Contributed equally to this work with: Maïlis Bietenhader, Alexandre Martos, Emmanuel Tetaud, Raeka S. Aiyar

    Affiliations: Université Bordeaux, IBGC, UMR5095 CNRS, Bordeaux, France, CNRS, IBGC, UMR5095 CNRS, Bordeaux, France

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  • Raeka S. Aiyar equal contributor,

    equal contributor Contributed equally to this work with: Maïlis Bietenhader, Alexandre Martos, Emmanuel Tetaud, Raeka S. Aiyar

    Affiliation: Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany

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  • Carole H. Sellem,

    Affiliation: Université Paris-Sud, Centre de Génétique Moléculaire, UPR3404, CNRS, Gif-sur-Yvette, France

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  • Roza Kucharczyk,

    Affiliations: Université Bordeaux, IBGC, UMR5095 CNRS, Bordeaux, France, CNRS, IBGC, UMR5095 CNRS, Bordeaux, France

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  • Sandra Clauder-Münster,

    Affiliation: Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany

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  • Marie-France Giraud,

    Affiliations: Université Bordeaux, IBGC, UMR5095 CNRS, Bordeaux, France, CNRS, IBGC, UMR5095 CNRS, Bordeaux, France

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  • François Godard,

    Affiliations: Université Bordeaux, IBGC, UMR5095 CNRS, Bordeaux, France, CNRS, IBGC, UMR5095 CNRS, Bordeaux, France

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  • Bénédicte Salin,

    Affiliations: Université Bordeaux, IBGC, UMR5095 CNRS, Bordeaux, France, CNRS, IBGC, UMR5095 CNRS, Bordeaux, France

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  • Isabelle Sagot,

    Affiliations: Université Bordeaux, IBGC, UMR5095 CNRS, Bordeaux, France, CNRS, IBGC, UMR5095 CNRS, Bordeaux, France

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  • Julien Gagneur,

    Affiliation: Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany

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  • Michelle Déquard-Chablat,

    Affiliations: Université Paris-Sud, Institut de Génétique et Microbiologie, UMR 8621, Orsay, France, CNRS, Orsay, France

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  • Véronique Contamine,

    Affiliations: Université Paris-Sud, Institut de Génétique et Microbiologie, UMR 8621, Orsay, France, CNRS, Orsay, France

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  • Sylvie Hermann-Le Denmat,

    Affiliations: Université Paris-Sud, Institut de Génétique et Microbiologie, UMR 8621, Orsay, France, CNRS, Orsay, France, Ecole Normale Supérieure, Paris, France

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  • Annie Sainsard-Chanet,

    Affiliation: Université Paris-Sud, Centre de Génétique Moléculaire, UPR3404, CNRS, Gif-sur-Yvette, France

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  • Lars M. Steinmetz mail,

    JP.dirago@ibgc.u-bordeaux2.fr (J-PdR); larsms@embl.de (LMS)

    Affiliation: Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany

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  • Jean-Paul di Rago mail

    JP.dirago@ibgc.u-bordeaux2.fr (J-PdR); larsms@embl.de (LMS)

    Affiliations: Université Bordeaux, IBGC, UMR5095 CNRS, Bordeaux, France, CNRS, IBGC, UMR5095 CNRS, Bordeaux, France

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  • Published: August 16, 2012
  • DOI: 10.1371/journal.pgen.1002876

About the Authors

Maïlis Bietenhader, Alexandre Martos, Emmanuel Tetaud, Roza Kucharczyk, Marie-France Giraud, François Godard, Bénédicte Salin, Isabelle Sagot, Jean-Paul di Rago
Université Bordeaux, IBGC, UMR5095 CNRS, Bordeaux, France
Maïlis Bietenhader, Alexandre Martos, Emmanuel Tetaud, Roza Kucharczyk, Marie-France Giraud, François Godard, Bénédicte Salin, Isabelle Sagot, Jean-Paul di Rago
CNRS, IBGC, UMR5095 CNRS, Bordeaux, France
Raeka S. Aiyar, Sandra Clauder-Münster, Julien Gagneur, Lars M. Steinmetz
Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany
Carole H. Sellem, Annie Sainsard-Chanet
Université Paris-Sud, Centre de Génétique Moléculaire, UPR3404, CNRS, Gif-sur-Yvette, France
Michelle Déquard-Chablat, Véronique Contamine, Sylvie Hermann-Le Denmat
Université Paris-Sud, Institut de Génétique et Microbiologie, UMR 8621, Orsay, France
Michelle Déquard-Chablat, Véronique Contamine, Sylvie Hermann-Le Denmat
CNRS, Orsay, France
Sylvie Hermann-Le Denmat
Ecole Normale Supérieure, Paris, France

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ET RSA AS-C LMS J-PdR MB AM. Performed the experiments: MB AM ET RSA CHS RK SC-M M-FG FG BS IS. Analyzed the data: MB AM ET RSA M-FG IS JG LMS J-PdR. Contributed reagents/materials/analysis tools: MD-C VC SH-LD. Wrote the paper: RSA LMS J-PdR.