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Research Article

UNC-40/DCC, SAX-3/Robo, and VAB-1/Eph Polarize F-Actin during Embryonic Morphogenesis by Regulating the WAVE/SCAR Actin Nucleation Complex

  • Yelena Y. Bernadskaya,

    Affiliation: Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry New Jersey, Piscataway, New Jersey, United States of America

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  • Andre Wallace,

    Affiliation: Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry New Jersey, Piscataway, New Jersey, United States of America

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  • Jillian Nguyen,

    Affiliation: Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry New Jersey, Piscataway, New Jersey, United States of America

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  • William A. Mohler,

    Affiliation: Department of Genetics and Developmental Biology and Center for Cell Analysis and Modeling, University of Connecticut Health Center, Farmington, Connecticut, United States of America

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  • Martha C. Soto mail

    sotomc@umdnj.edu

    Affiliation: Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry New Jersey, Piscataway, New Jersey, United States of America

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  • Published: August 02, 2012
  • DOI: 10.1371/journal.pgen.1002863

About the Authors

Yelena Y. Bernadskaya, Andre Wallace, Jillian Nguyen, Martha C. Soto
Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry New Jersey, Piscataway, New Jersey, United States of America
William A. Mohler
Department of Genetics and Developmental Biology and Center for Cell Analysis and Modeling, University of Connecticut Health Center, Farmington, Connecticut, United States of America

Corresponding Author

Email: sotomc@umdnj.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YYB MCS. Performed the experiments: YYB AW JN MCS. Analyzed the data: YYB AW MCS. Contributed reagents/materials/analysis tools: JN WAM. Wrote the paper: YYB MCS.