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Research Article

The SCFDia2 Ubiquitin E3 Ligase Ubiquitylates Sir4 and Functions in Transcriptional Silencing

  • Rebecca J. Burgess,

    Affiliation: Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

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  • Hui Zhou,

    Affiliation: Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

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  • Junhong Han,

    Affiliation: Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

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  • Qing Li,

    Affiliation: Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

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  • Zhiguo Zhang mail

    zhang.zhiguo@mayo.edu

    Affiliation: Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

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  • Published: July 26, 2012
  • DOI: 10.1371/journal.pgen.1002846

About the Authors

Rebecca J. Burgess, Hui Zhou, Junhong Han, Qing Li, Zhiguo Zhang
Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

Corresponding Author

Email: zhang.zhiguo@mayo.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RJB ZZ. Performed the experiments: RJB HZ JH QL. Analyzed the data: RJB HZ JH QL ZZ. Wrote the paper: RJB ZZ.