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Research Article

Rescuing Alu: Recovery of New Inserts Shows LINE-1 Preserves Alu Activity through A-Tail Expansion

  • Bradley J. Wagstaff,

    Affiliation: Tulane Cancer Center, Department of Epidemiology, Tulane University, New Orleans, Louisiana, United States of America

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  • Dale J. Hedges,

    Affiliation: Hussman Institute for Human Genomics, Dr. John T. Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, Florida, United States of America

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  • Rebecca S. Derbes,

    Affiliation: Tulane Cancer Center, Department of Epidemiology, Tulane University, New Orleans, Louisiana, United States of America

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  • Rebeca Campos Sanchez,

    Affiliation: Department of Biology, Center for Medical Genomics, Pennsylvania State University, University Park, Pennsylvania, United States of America

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  • Francesca Chiaromonte,

    Affiliation: Department of Biology, Center for Medical Genomics, Pennsylvania State University, University Park, Pennsylvania, United States of America

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  • Kateryna D. Makova,

    Affiliation: Department of Biology, Center for Medical Genomics, Pennsylvania State University, University Park, Pennsylvania, United States of America

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  • Astrid M. Roy-Engel mail

    aengel@tulane.edu

    Affiliation: Tulane Cancer Center, Department of Epidemiology, Tulane University, New Orleans, Louisiana, United States of America

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  • Published: August 09, 2012
  • DOI: 10.1371/journal.pgen.1002842

About the Authors

Bradley J. Wagstaff, Rebecca S. Derbes, Astrid M. Roy-Engel
Tulane Cancer Center, Department of Epidemiology, Tulane University, New Orleans, Louisiana, United States of America
Dale J. Hedges
Hussman Institute for Human Genomics, Dr. John T. Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, Florida, United States of America
Rebeca Campos Sanchez, Francesca Chiaromonte, Kateryna D. Makova
Department of Biology, Center for Medical Genomics, Pennsylvania State University, University Park, Pennsylvania, United States of America

Corresponding Author

Email: aengel@tulane.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BJW KDM AMR-E. Performed the experiments: BJW RSD RCS AMR-E. Analyzed the data: DJH FC KDM RCS BJW AMR-E. Contributed reagents/materials/analysis tools: KDM RCS FC. Wrote the paper: BJW AMR-E. Edited the article: DJH KDM RCS BJW.