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Research Article

Gene Expression Profiles in Parkinson Disease Prefrontal Cortex Implicate FOXO1 and Genes under Its Transcriptional Regulation

  • Alexandra Dumitriu mail,

    adumitri@bu.edu

    Affiliations: Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America, Bioinformatics Program, Boston University College of Arts and Sciences, Boston, Massachusetts, United States of America

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  • Jeanne C. Latourelle,

    Affiliation: Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America

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  • Tiffany C. Hadzi,

    Affiliation: Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America

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  • Nathan Pankratz,

    Affiliation: Department of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, Minneapolis, Minnesota, United States of America

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  • Dan Garza,

    Affiliation: Proteostasis Therapeutics, Cambridge, Massachusetts, United States of America

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  • John P. Miller,

    Affiliation: Proteostasis Therapeutics, Cambridge, Massachusetts, United States of America

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  • Jeffery M. Vance,

    Affiliation: Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Tatiana Foroud,

    Affiliation: Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

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  • Thomas G. Beach,

    Affiliation: Banner Sun Health Research Institute, Sun City, Arizona, United States of America

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  • Richard H. Myers

    Affiliations: Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America, Bioinformatics Program, Boston University College of Arts and Sciences, Boston, Massachusetts, United States of America

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  • Published: June 28, 2012
  • DOI: 10.1371/journal.pgen.1002794

About the Authors

Alexandra Dumitriu, Jeanne C. Latourelle, Tiffany C. Hadzi, Richard H. Myers
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America
Alexandra Dumitriu, Richard H. Myers
Bioinformatics Program, Boston University College of Arts and Sciences, Boston, Massachusetts, United States of America
Nathan Pankratz
Department of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, Minneapolis, Minnesota, United States of America
Dan Garza, John P. Miller
Proteostasis Therapeutics, Cambridge, Massachusetts, United States of America
Jeffery M. Vance
Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America
Tatiana Foroud
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
Thomas G. Beach
Banner Sun Health Research Institute, Sun City, Arizona, United States of America

Corresponding Author

Email: adumitri@bu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AD JCL DG RHM. Performed the experiments: DG JPM. Analyzed the data: AD JCL NP. Contributed reagents/materials/analysis tools: TCH JMV TF TGB RHM. Wrote the paper: AD JCL RHM.