Advertisement
Research Article

The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits

  • Benjamin F. Voight equal contributor,

    equal contributor Contributed equally to this work with: Benjamin F. Voight, Hyun Min Kang

    Affiliations: Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Pharmacology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Hyun Min Kang equal contributor,

    equal contributor Contributed equally to this work with: Benjamin F. Voight, Hyun Min Kang

    Affiliation: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Jun Ding,

    Affiliation: Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

    X
  • Cameron D. Palmer,

    Affiliations: Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Divisions of Endocrinology and Genetics and Program in Genomics, Children's Hospital, Boston, Massachusetts, United States of America

    X
  • Carlo Sidore,

    Affiliations: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America, Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy, Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy

    X
  • Peter S. Chines,

    Affiliation: Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America

    X
  • Noël P. Burtt,

    Affiliation: Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    X
  • Christian Fuchsberger,

    Affiliation: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Yanming Li,

    Affiliation: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Jeanette Erdmann,

    Affiliation: Universität zu Lübeck, Medizinische Klinik II, and Nordic Center of Cardiovascular Research, Lübeck, Germany

    X
  • Timothy M. Frayling,

    Affiliation: Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, United Kingdom

    X
  • Iris M. Heid,

    Affiliations: Department of Epidemiology and Preventive Medicine, University Hospital Regensburg, Regensburg, Germany, Helmholtz Zentrum München—German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany

    X
  • Anne U. Jackson,

    Affiliation: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Toby Johnson,

    Affiliation: Clinical Pharmacology and Barts and the London Genome Centre, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom

    X
  • Tuomas O. Kilpeläinen,

    Affiliation: MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

    X
  • Cecilia M. Lindgren,

    Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

    X
  • Andrew P. Morris,

    Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

    X
  • Inga Prokopenko,

    Affiliations: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, University of Oxford, Oxford, United Kingdom

    X
  • Joshua C. Randall,

    Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

    X
  • Richa Saxena,

    Affiliations: Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

    X
  • Nicole Soranzo,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

    X
  • Elizabeth K. Speliotes,

    Affiliations: Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Internal Medicine, Division of Gastroenterology and Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Tanya M. Teslovich,

    Affiliation: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Eleanor Wheeler,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

    X
  • Jared Maguire,

    Affiliation: Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    X
  • Melissa Parkin,

    Affiliation: Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    X
  • Simon Potter,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

    X
  • N. William Rayner,

    Affiliations: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, University of Oxford, Oxford, United Kingdom, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

    X
  • Neil Robertson,

    Affiliations: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, University of Oxford, Oxford, United Kingdom

    X
  • Kathleen Stirrups,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

    X
  • Wendy Winckler,

    Affiliation: Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    X
  • Serena Sanna,

    Affiliation: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy

    X
  • Antonella Mulas,

    Affiliation: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy

    X
  • Ramaiah Nagaraja,

    Affiliation: Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

    X
  • Francesco Cucca,

    Affiliations: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy, Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy

    X
  • Inês Barroso,

    Affiliations: Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom, University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

    X
  • Panos Deloukas,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

    X
  • Ruth J. F. Loos,

    Affiliation: MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

    X
  • Sekar Kathiresan,

    Affiliations: Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Patricia B. Munroe,

    Affiliation: Clinical Pharmacology and Barts and the London Genome Centre, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom

    X
  • Christopher Newton-Cheh,

    Affiliations: Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Arne Pfeufer,

    Affiliations: Institute of Human Genetics, Klinikum Rechts der Isar Technische Universität München, Munich, Germany, Institute of Human Genetics, Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt, Neuherberg, Germany, EURAC Center of Biomedicine, Bolzano, Italy

    X
  • Nilesh J. Samani,

    Affiliations: Department of Cardiovascular Sciences, Glenfield Hospital, University of Leicester, Leicester, United Kingdom, Leicester NIHR Biomedical Research Unit in Coronary Artery Disease, Glenfield Hospital, Leicester, United Kingdom

    X
  • Heribert Schunkert,

    Affiliation: Universität zu Lübeck, Medizinische Klinik II, and Nordic Center of Cardiovascular Research, Lübeck, Germany

    X
  • Joel N. Hirschhorn,

    Affiliations: Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Divisions of Endocrinology and Genetics and Program in Genomics, Children's Hospital, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • David Altshuler mail,

    altshuler@molbio.mgh.harvard.edu (DA); mark.mccarthy@drl.ox.ac.uk (MIM); goncalo@umich.edu (GRA); boehnke@umich.edu (MB)

    Affiliations: Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Molecular Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America

    X
  • Mark I. McCarthy mail,

    altshuler@molbio.mgh.harvard.edu (DA); mark.mccarthy@drl.ox.ac.uk (MIM); goncalo@umich.edu (GRA); boehnke@umich.edu (MB)

    Affiliations: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, University of Oxford, Oxford, United Kingdom, Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, United Kingdom

    X
  • Gonçalo R. Abecasis mail,

    altshuler@molbio.mgh.harvard.edu (DA); mark.mccarthy@drl.ox.ac.uk (MIM); goncalo@umich.edu (GRA); boehnke@umich.edu (MB)

    Affiliation: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Michael Boehnke mail

    altshuler@molbio.mgh.harvard.edu (DA); mark.mccarthy@drl.ox.ac.uk (MIM); goncalo@umich.edu (GRA); boehnke@umich.edu (MB)

    Affiliation: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Published: August 02, 2012
  • DOI: 10.1371/journal.pgen.1002793

About the Authors

Benjamin F. Voight, Cameron D. Palmer, Noël P. Burtt, Richa Saxena, Elizabeth K. Speliotes, Jared Maguire, Melissa Parkin, Wendy Winckler, Sekar Kathiresan, Christopher Newton-Cheh, Joel N. Hirschhorn, David Altshuler
Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Benjamin F. Voight
Department of Pharmacology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
Hyun Min Kang, Carlo Sidore, Christian Fuchsberger, Yanming Li, Anne U. Jackson, Tanya M. Teslovich, Gonçalo R. Abecasis, Michael Boehnke
Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America
Jun Ding, Ramaiah Nagaraja
Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
Cameron D. Palmer, Joel N. Hirschhorn
Divisions of Endocrinology and Genetics and Program in Genomics, Children's Hospital, Boston, Massachusetts, United States of America
Carlo Sidore, Serena Sanna, Antonella Mulas, Francesco Cucca
Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy
Carlo Sidore, Francesco Cucca
Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy
Peter S. Chines
Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America
Jeanette Erdmann, Heribert Schunkert
Universität zu Lübeck, Medizinische Klinik II, and Nordic Center of Cardiovascular Research, Lübeck, Germany
Timothy M. Frayling
Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, United Kingdom
Iris M. Heid
Department of Epidemiology and Preventive Medicine, University Hospital Regensburg, Regensburg, Germany
Iris M. Heid
Helmholtz Zentrum München—German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
Toby Johnson, Patricia B. Munroe
Clinical Pharmacology and Barts and the London Genome Centre, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom
Tuomas O. Kilpeläinen, Ruth J. F. Loos
MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom
Cecilia M. Lindgren, Andrew P. Morris, Inga Prokopenko, Joshua C. Randall, N. William Rayner, Neil Robertson, Mark I. McCarthy
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
Inga Prokopenko, N. William Rayner, Neil Robertson, Mark I. McCarthy
Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, University of Oxford, Oxford, United Kingdom
Richa Saxena, Sekar Kathiresan, Christopher Newton-Cheh, David Altshuler
Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Richa Saxena
Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Nicole Soranzo, Eleanor Wheeler, Simon Potter, N. William Rayner, Kathleen Stirrups, Inês Barroso, Panos Deloukas
Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
Elizabeth K. Speliotes
Department of Internal Medicine, Division of Gastroenterology and Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America
Inês Barroso
University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom
Sekar Kathiresan, Christopher Newton-Cheh
Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Sekar Kathiresan, Christopher Newton-Cheh, David Altshuler
Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
Arne Pfeufer
Institute of Human Genetics, Klinikum Rechts der Isar Technische Universität München, Munich, Germany
Arne Pfeufer
Institute of Human Genetics, Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt, Neuherberg, Germany
Arne Pfeufer
EURAC Center of Biomedicine, Bolzano, Italy
Nilesh J. Samani
Department of Cardiovascular Sciences, Glenfield Hospital, University of Leicester, Leicester, United Kingdom
Nilesh J. Samani
Leicester NIHR Biomedical Research Unit in Coronary Artery Disease, Glenfield Hospital, Leicester, United Kingdom
Joel N. Hirschhorn, David Altshuler
Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
David Altshuler
Department of Molecular Biology, Harvard Medical School, Boston, Massachusetts, United States of America
David Altshuler
Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Mark I. McCarthy
Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BFV HMK JNH DA MIM GRA MB. Analyzed the data: BFV HMK JD CDP CS PSC NPB CF YL JE TMF IMH AUJ TJ TOK CML APM IP JCR RS NS EKS TMT EW JM MP SP NWR NR KS WW SS AM. Contributed reagents/materials/analysis tools: AM RN FC IB PD RJFL SK PBM CN-C AP NJS HS. Wrote the paper: BFV HMK GRA MB. Critically revised the manuscript, including comments and feedback: BFV HMK JE TMF TOK CML NS NWR SS RN IB RJFL SK CN-C NJS JNH DA MIM GRA MB.