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Research Article

The CCR4-NOT Complex Is Implicated in the Viability of Aneuploid Yeasts

  • Yoshie Tange,

    Affiliations: Kazusa DNA Research Institute, Kisarazu, Chiba, Japan, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan

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  • Atsushi Kurabayashi,

    Affiliation: Kazusa DNA Research Institute, Kisarazu, Chiba, Japan

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  • Bunshiro Goto,

    Affiliation: Kazusa DNA Research Institute, Kisarazu, Chiba, Japan

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  • Kwang-Lae Hoe,

    Affiliation: Chungnam National University, Graduate School of New Drug Discovery and Development, Yusong-gu, Daejeon, Korea

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  • Dong-Uk Kim,

    Affiliation: Aging Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yusong-gu, Daejeon, Korea

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  • Han-Oh Park,

    Affiliation: Bioneer Corporation, Daejeon, Korea

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  • Jacqueline Hayles,

    Affiliation: Cancer Research UK, The London Research Institute, London, United Kingdom

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  • Yuji Chikashige,

    Affiliation: National Institute of Information and Communications Technology, Kobe, Japan

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  • Chihiro Tsutumi,

    Affiliation: National Institute of Information and Communications Technology, Kobe, Japan

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  • Yasushi Hiraoka,

    Affiliations: Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan, National Institute of Information and Communications Technology, Kobe, Japan

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  • Fumiaki Yamao,

    Affiliation: National Institute of Genetics, Mishima, Shizuoka, Japan

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  • Paul Nurse,

    Affiliations: Cancer Research UK, The London Research Institute, London, United Kingdom, The Rockefeller University, New York, New York, United States of America

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  • Osami Niwa mail

    niwa@kazusa.or.jp

    Affiliations: Kazusa DNA Research Institute, Kisarazu, Chiba, Japan, The Rockefeller University, New York, New York, United States of America

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  • Published: June 21, 2012
  • DOI: 10.1371/journal.pgen.1002776

About the Authors

Yoshie Tange, Atsushi Kurabayashi, Bunshiro Goto, Osami Niwa
Kazusa DNA Research Institute, Kisarazu, Chiba, Japan
Yoshie Tange, Yasushi Hiraoka
Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan
Kwang-Lae Hoe
Chungnam National University, Graduate School of New Drug Discovery and Development, Yusong-gu, Daejeon, Korea
Dong-Uk Kim
Aging Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yusong-gu, Daejeon, Korea
Han-Oh Park
Bioneer Corporation, Daejeon, Korea
Jacqueline Hayles, Paul Nurse
Cancer Research UK, The London Research Institute, London, United Kingdom
Yuji Chikashige, Chihiro Tsutumi, Yasushi Hiraoka
National Institute of Information and Communications Technology, Kobe, Japan
Fumiaki Yamao
National Institute of Genetics, Mishima, Shizuoka, Japan
Paul Nurse, Osami Niwa
The Rockefeller University, New York, New York, United States of America

Corresponding Author

Email: niwa@kazusa.or.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YT ON. Performed the experiments: YT AK BG CT ON. Analyzed the data: YT YC YH ON. Contributed reagents/materials/analysis tools: K-LH D-UK H-OP JH YC CT YH FY. Wrote the paper: PN ON.