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Research Article

A Mouse Model of Acrodermatitis Enteropathica: Loss of Intestine Zinc Transporter ZIP4 (Slc39a4) Disrupts the Stem Cell Niche and Intestine Integrity

  • Jim Geiser,

    Affiliation: Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America

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  • Koen J. T. Venken,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Robert C. De Lisle,

    Affiliation: Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America

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  • Glen K. Andrews mail

    gandrews@kumc.edu

    Affiliations: Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America, Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America

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  • Published: June 21, 2012
  • DOI: 10.1371/journal.pgen.1002766

About the Authors

Jim Geiser, Glen K. Andrews
Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America
Koen J. T. Venken
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
Robert C. De Lisle, Glen K. Andrews
Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America

Corresponding Author

Email: gandrews@kumc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GKA JG RCDL KJTV. Performed the experiments: GKA JG. Analyzed the data: GKA JG RCDL. Contributed reagents/materials/analysis tools: KJTV RCDL GKA. Wrote the paper: GKA JG RCDL KTJV.