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Research Article

Detecting Individual Sites Subject to Episodic Diversifying Selection

  • Ben Murrell,

    Affiliations: Biomedical Informatics Research Division, eHealth Research and Innovation Platform, Medical Research Council, Tygerberg, South Africa, Computer Science Division, Department of Mathematical Sciences, Stellenbosch University, Stellenbosch, South Africa

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  • Joel O. Wertheim,

    Affiliation: Department of Pathology, University of California San Diego, La Jolla, California, United States of America

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  • Sasha Moola,

    Affiliation: Computer Science Division, Department of Mathematical Sciences, Stellenbosch University, Stellenbosch, South Africa

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  • Thomas Weighill,

    Affiliation: Computer Science Division, Department of Mathematical Sciences, Stellenbosch University, Stellenbosch, South Africa

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  • Konrad Scheffler,

    Affiliations: Computer Science Division, Department of Mathematical Sciences, Stellenbosch University, Stellenbosch, South Africa, Department of Medicine, University of California San Diego, La Jolla, California, United States of America

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  • Sergei L. Kosakovsky Pond mail

    spond@ucsd.edu

    Affiliation: Department of Medicine, University of California San Diego, La Jolla, California, United States of America

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  • Published: July 12, 2012
  • DOI: 10.1371/journal.pgen.1002764

About the Authors

Ben Murrell
Biomedical Informatics Research Division, eHealth Research and Innovation Platform, Medical Research Council, Tygerberg, South Africa
Ben Murrell, Sasha Moola, Thomas Weighill, Konrad Scheffler
Computer Science Division, Department of Mathematical Sciences, Stellenbosch University, Stellenbosch, South Africa
Joel O. Wertheim
Department of Pathology, University of California San Diego, La Jolla, California, United States of America
Konrad Scheffler, Sergei L. Kosakovsky Pond
Department of Medicine, University of California San Diego, La Jolla, California, United States of America

Corresponding Author

Email: spond@ucsd.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BM KS SLKP. Performed the experiments: BM JOW SM TW SLKP. Analyzed the data: BM JOW SM TW SLKP. Contributed reagents/materials/analysis tools: BM SLKP. Wrote the paper: BM JOW KS SLKP.