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Research Article

Polymorphisms in the Mitochondrial Ribosome Recycling Factor EF-G2mt/MEF2 Compromise Cell Respiratory Function and Increase Atorvastatin Toxicity

  • Sylvie Callegari,

    Affiliation: School of Pharmacy and Medical Sciences, Division of Health Sciences, University of South Australia, Adelaide, South Australia, Australia

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  • Philip A. Gregory,

    Affiliations: Division of Human Immunology, Centre for Cancer Biology, SA Pathology, Adelaide, South Australia, Australia, Discipline of Medicine, The University of Adelaide, Adelaide, South Australia, Australia

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  • Matthew J. Sykes,

    Affiliations: School of Pharmacy and Medical Sciences, Division of Health Sciences, University of South Australia, Adelaide, South Australia, Australia, Sansom Institute, Division of Health Sciences, University of South Australia, Adelaide, South Australia, Australia

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  • Jennifer Bellon,

    Affiliation: Australian Wine Research Institute, Glen Osmond, South Australia, Australia

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  • Stuart Andrews,

    Affiliation: School of Pharmacy and Medical Sciences, Division of Health Sciences, University of South Australia, Adelaide, South Australia, Australia

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  • Ross A. McKinnon,

    Affiliation: Flinders Centre for Innovation in Cancer, School of Medicine, Flinders University, Bedford Park, South Australia, Australia

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  • Miguel A. de Barros Lopes mail

    miguel.debarroslopes@unisa.edu.au

    Affiliation: School of Pharmacy and Medical Sciences, Division of Health Sciences, University of South Australia, Adelaide, South Australia, Australia

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  • Published: June 14, 2012
  • DOI: 10.1371/journal.pgen.1002755

About the Authors

Sylvie Callegari, Matthew J. Sykes, Stuart Andrews, Miguel A. de Barros Lopes
School of Pharmacy and Medical Sciences, Division of Health Sciences, University of South Australia, Adelaide, South Australia, Australia
Philip A. Gregory
Division of Human Immunology, Centre for Cancer Biology, SA Pathology, Adelaide, South Australia, Australia
Philip A. Gregory
Discipline of Medicine, The University of Adelaide, Adelaide, South Australia, Australia
Matthew J. Sykes
Sansom Institute, Division of Health Sciences, University of South Australia, Adelaide, South Australia, Australia
Jennifer Bellon
Australian Wine Research Institute, Glen Osmond, South Australia, Australia
Ross A. McKinnon
Flinders Centre for Innovation in Cancer, School of Medicine, Flinders University, Bedford Park, South Australia, Australia

Corresponding Author

Email: miguel.debarroslopes@unisa.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SC PAG MJS JB SA RAM MAdBL. Performed the experiments: SC. Analyzed the data: SC. Contributed reagents/materials/analysis tools: PAG JB. Wrote the paper: SC MAdBL.