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Research Article

MicroRNA93 Regulates Proliferation and Differentiation of Normal and Malignant Breast Stem Cells

  • Suling Liu mail,

    sulingl@med.umich.edu (SL); mwicha@umich.edu (MSW)

    Affiliation: Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Shivani H. Patel,

    Affiliation: Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Christophe Ginestier,

    Affiliation: Centre de Recherche en Cancérologie de Marseille, Laboratoire d'Oncologie Moléculaire, UMR891 Inserm/Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France

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  • Ingrid Ibarra,

    Affiliation: Program in Genetics and Bioinformatics, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America

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  • Rachel Martin-Trevino,

    Affiliation: Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Shoumin Bai,

    Affiliation: Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Sean P. McDermott,

    Affiliation: Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Li Shang,

    Affiliation: Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Jia Ke,

    Affiliation: Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Sing J. Ou,

    Affiliation: Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Amber Heath,

    Affiliation: Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Kevin J. Zhang,

    Affiliation: Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Hasan Korkaya,

    Affiliation: Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Shawn G. Clouthier,

    Affiliation: Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Emmanuelle Charafe-Jauffret,

    Affiliation: Centre de Recherche en Cancérologie de Marseille, Laboratoire d'Oncologie Moléculaire, UMR891 Inserm/Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France

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  • Daniel Birnbaum,

    Affiliation: Centre de Recherche en Cancérologie de Marseille, Laboratoire d'Oncologie Moléculaire, UMR891 Inserm/Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France

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  • Gregory J. Hannon,

    Affiliation: Program in Genetics and Bioinformatics, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America

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  • Max S. Wicha mail

    sulingl@med.umich.edu (SL); mwicha@umich.edu (MSW)

    Affiliation: Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Published: June 07, 2012
  • DOI: 10.1371/journal.pgen.1002751

About the Authors

Suling Liu, Shivani H. Patel, Rachel Martin-Trevino, Shoumin Bai, Sean P. McDermott, Li Shang, Jia Ke, Sing J. Ou, Amber Heath, Kevin J. Zhang, Hasan Korkaya, Shawn G. Clouthier, Max S. Wicha
Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America
Christophe Ginestier, Emmanuelle Charafe-Jauffret, Daniel Birnbaum
Centre de Recherche en Cancérologie de Marseille, Laboratoire d'Oncologie Moléculaire, UMR891 Inserm/Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France
Ingrid Ibarra, Gregory J. Hannon
Program in Genetics and Bioinformatics, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America

Corresponding Authors

Competing Interests

MSW is a scientific advisor and has financial holdings in OncoMed Pharmaceuticals.

Author Contributions

Conceived and designed the experiments: SL CG DB GJH MSW. Performed the experiments: SL SHP CG II RM-T SB SPM LS JK SJO AH KJZ. Analyzed the data: SL CG II HK SGC EC-J MSW. Contributed reagents/materials/analysis tools: SL DB GJH MSW. Wrote the paper: SL MSW.