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Research Article

In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases

  • Julia Arand,

    Affiliation: Department of Biological Sciences, Institute of Genetics/Epigenetics, University of Saarland, Saarbrücken, Germany

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  • David Spieler,

    Affiliation: Department of Computer Science, University of Saarland, Saarbrücken, Germany

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  • Tommy Karius,

    Affiliation: Department of Biological Sciences, Institute of Genetics/Epigenetics, University of Saarland, Saarbrücken, Germany

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  • Miguel R. Branco,

    Affiliations: Epigenetics Programme, Babraham Institute, Cambridge, United Kingdom, Centre for Trophoblast Research, University of Cambridge, Cambridge, United Kingdom

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  • Daniela Meilinger,

    Affiliation: Department of Biology II, LMU München, Biozentrum Martinsried, Martinsried, Germany

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  • Alexander Meissner,

    Affiliation: Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, United States of America

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  • Thomas Jenuwein,

    Affiliation: MPI for Immunology and Epigenetics, Freiburg, Germany

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  • Guoliang Xu,

    Affiliation: Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China

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  • Heinrich Leonhardt,

    Affiliation: Department of Biology II, LMU München, Biozentrum Martinsried, Martinsried, Germany

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  • Verena Wolf,

    Affiliation: Department of Computer Science, University of Saarland, Saarbrücken, Germany

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  • Jörn Walter mail

    j.walter@mx.uni-saarland.de

    Affiliation: Department of Biological Sciences, Institute of Genetics/Epigenetics, University of Saarland, Saarbrücken, Germany

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  • Published: June 28, 2012
  • DOI: 10.1371/journal.pgen.1002750

About the Authors

Julia Arand, Tommy Karius, Jörn Walter
Department of Biological Sciences, Institute of Genetics/Epigenetics, University of Saarland, Saarbrücken, Germany
David Spieler, Verena Wolf
Department of Computer Science, University of Saarland, Saarbrücken, Germany
Miguel R. Branco
Epigenetics Programme, Babraham Institute, Cambridge, United Kingdom
Miguel R. Branco
Centre for Trophoblast Research, University of Cambridge, Cambridge, United Kingdom
Daniela Meilinger, Heinrich Leonhardt
Department of Biology II, LMU München, Biozentrum Martinsried, Martinsried, Germany
Alexander Meissner
Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, United States of America
Thomas Jenuwein
MPI for Immunology and Epigenetics, Freiburg, Germany
Guoliang Xu
Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China

Corresponding Author

Email: j.walter@mx.uni-saarland.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JW VW. Performed the experiments: JA DS TK. Analyzed the data: JA DS MRB. Contributed reagents/materials/analysis tools: AM GX TJ HL DM. Wrote the paper: JA JW VW.