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Research Article

Fitness Landscape Transformation through a Single Amino Acid Change in the Rho Terminator

  • Peter L. Freddolino equal contributor,

    equal contributor Contributed equally to this work with: Peter L. Freddolino, Hani Goodarzi

    Affiliation: Joint Centers for Systems Biology, Columbia University, New York, New York, United States of America

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  • Hani Goodarzi equal contributor,

    equal contributor Contributed equally to this work with: Peter L. Freddolino, Hani Goodarzi

    Affiliation: Joint Centers for Systems Biology, Columbia University, New York, New York, United States of America

    Current address: Laboratory of Systems Cancer Biology, Rockefeller University, New York, New York, United States of America

    X
  • Saeed Tavazoie mail

    st2744@columbia.edu

    Affiliations: Joint Centers for Systems Biology, Columbia University, New York, New York, United States of America, Department of Biochemistry and Molecular Biology, Columbia University, New York, New York, United States of America

    X
  • Published: May 31, 2012
  • DOI: 10.1371/journal.pgen.1002744

About the Authors

Peter L. Freddolino, Hani Goodarzi, Saeed Tavazoie
Joint Centers for Systems Biology, Columbia University, New York, New York, United States of America
Saeed Tavazoie
Department of Biochemistry and Molecular Biology, Columbia University, New York, New York, United States of America

Corresponding Author

Email: st2744@columbia.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PLF HG ST. Performed the experiments: PLF HG. Analyzed the data: PLF HG ST. Contributed reagents/materials/analysis tools: PLF HG. Wrote the paper: PLF HG ST.