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Research Article

Stimulation of Host Immune Defenses by a Small Molecule Protects C. elegans from Bacterial Infection

  • Read Pukkila-Worley,

    Affiliations: Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Rhonda Feinbaum,

    Affiliations: Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Natalia V. Kirienko,

    Affiliations: Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Jonah Larkins-Ford,

    Affiliations: Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Annie L. Conery,

    Affiliations: Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Frederick M. Ausubel mail

    ausubel@molbio.mgh.harvard.edu

    Affiliations: Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: June 14, 2012
  • DOI: 10.1371/journal.pgen.1002733

About the Authors

Read Pukkila-Worley
Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Read Pukkila-Worley, Rhonda Feinbaum, Natalia V. Kirienko, Jonah Larkins-Ford, Annie L. Conery, Frederick M. Ausubel
Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Read Pukkila-Worley, Rhonda Feinbaum, Natalia V. Kirienko, Jonah Larkins-Ford, Annie L. Conery, Frederick M. Ausubel
Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Author

Email: ausubel@molbio.mgh.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RP-W RF NVK JL-F ALC FMA. Performed the experiments: RP-W RF NVK JL-F. Analyzed the data: RP-W RF NVK JL-F. Wrote the paper: RP-W FMA.