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Research Article

Deletion of PTH Rescues Skeletal Abnormalities and High Osteopontin Levels in Klotho−/− Mice

  • Quan Yuan,

    Affiliations: Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts, United States of America, State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China

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  • Tadatoshi Sato,

    Affiliation: Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts, United States of America

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  • Michael Densmore,

    Affiliation: Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts, United States of America

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  • Hiroaki Saito,

    Affiliation: Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, United States of America

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  • Christiane Schüler,

    Affiliation: Institute of Physiology, Pathophysiology, and Biophysics, Department of Biomedical Sciences, University of Veterinary Medicine, Vienna, Austria

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  • Reinhold G. Erben,

    Affiliation: Institute of Physiology, Pathophysiology, and Biophysics, Department of Biomedical Sciences, University of Veterinary Medicine, Vienna, Austria

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  • Beate Lanske mail

    beate_lanske@hsdm.harvard.edu

    Affiliation: Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts, United States of America

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  • Published: May 17, 2012
  • DOI: 10.1371/journal.pgen.1002726

About the Authors

Quan Yuan, Tadatoshi Sato, Michael Densmore, Beate Lanske
Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts, United States of America
Quan Yuan
State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China
Hiroaki Saito
Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, United States of America
Christiane Schüler, Reinhold G. Erben
Institute of Physiology, Pathophysiology, and Biophysics, Department of Biomedical Sciences, University of Veterinary Medicine, Vienna, Austria

Corresponding Author

Email: beate_lanske@hsdm.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: QY BL. Performed the experiments: QY TS MD HS CS. Analyzed the data: QY TS RGE BL. Contributed reagents/materials/analysis tools: TS CS. Wrote the paper: QY MD BL.