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Research Article

Psip1/Ledgf p52 Binds Methylated Histone H3K36 and Splicing Factors and Contributes to the Regulation of Alternative Splicing

  • Madapura M. Pradeepa,

    Affiliation: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Heidi G. Sutherland,

    Affiliation: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Jernej Ule,

    Affiliation: MRC Laboratory of Molecular Biology, Cambridge, United Kingdom

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  • Graeme R. Grimes,

    Affiliation: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Wendy A. Bickmore mail

    W.Bickmore@hgu.mrc.ac.uk

    Affiliation: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Published: May 17, 2012
  • DOI: 10.1371/journal.pgen.1002717

About the Authors

Madapura M. Pradeepa, Heidi G. Sutherland, Graeme R. Grimes, Wendy A. Bickmore
MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
Jernej Ule
MRC Laboratory of Molecular Biology, Cambridge, United Kingdom

Corresponding Author

Email: W.Bickmore@hgu.mrc.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MMP WAB. Performed the experiments: MMP HGS JU. Analyzed the data: MMP JU GRG. Wrote the paper: MMP WAB.