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Research Article

Genome-Wide Association of Pericardial Fat Identifies a Unique Locus for Ectopic Fat

  • Caroline S. Fox mail,

    foxca@nhlbi.nih.gov (CSF); yoliu@wfubmc.edu (YL)

    Affiliations: Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, United States of America, Center for Population Studies, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, United States of America, Division of Endocrinology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Charles C. White,

    Affiliations: Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, United States of America, Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

    X
  • Kurt Lohman,

    Affiliation: Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

    X
  • Nancy Heard-Costa,

    Affiliation: Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America

    X
  • Paul Cohen,

    Affiliation: Division of Cardiovascular Medicine and Department of Cancer Biology, Brigham and Women's Hospital and Dana Farber Cancer Institute, Boston, Massachusetts, United States of America

    X
  • Yingying Zhang,

    Affiliation: Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America

    X
  • Andrew D. Johnson,

    Affiliations: Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, United States of America, Center for Population Studies, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, United States of America

    X
  • Valur Emilsson,

    Affiliation: Icelandic Heart Association, Hjartavernd, Iceland

    X
  • Ching-Ti Liu,

    Affiliations: Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, United States of America, Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

    X
  • Y.-D. Ida Chen,

    Affiliation: Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Kent D. Taylor,

    Affiliation: Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Matthew Allison,

    Affiliation: Department of Preventive Medicine, University of California San Diego, La Jolla, California, United States of America

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  • Matthew Budoff,

    Affiliation: Los Angeles Biomedical Research Institute, Torrance, California, United States of America

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  • The CARDIoGRAM Consortium,
  • Jerome I. Rotter,

    Affiliation: Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • J. Jeffrey Carr,

    Affiliation: Departments of Radiologic Sciences, Internal Medicine-Cardiology, and Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Udo Hoffmann,

    Affiliation: Cardiac MR, PET, CT Program and the Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Jingzhong Ding,

    Affiliation: Department of Internal Medicine/Geriatrics, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

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  • L. Adrienne Cupples,

    Affiliations: Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, United States of America, Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

    X
  • Yongmei Liu mail

    foxca@nhlbi.nih.gov (CSF); yoliu@wfubmc.edu (YL)

    Affiliation: Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

    X
  • Published: May 10, 2012
  • DOI: 10.1371/journal.pgen.1002705

About the Authors

Caroline S. Fox, Charles C. White, Andrew D. Johnson, Ching-Ti Liu, L. Adrienne Cupples
Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, United States of America
Caroline S. Fox, Andrew D. Johnson
Center for Population Studies, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, United States of America
Caroline S. Fox
Division of Endocrinology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
Charles C. White, Ching-Ti Liu, L. Adrienne Cupples
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
Kurt Lohman, Yongmei Liu
Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America
Nancy Heard-Costa
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America
Paul Cohen
Division of Cardiovascular Medicine and Department of Cancer Biology, Brigham and Women's Hospital and Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
Yingying Zhang
Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
Valur Emilsson
Icelandic Heart Association, Hjartavernd, Iceland
Y.-D. Ida Chen, Kent D. Taylor, Jerome I. Rotter
Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
Matthew Allison
Department of Preventive Medicine, University of California San Diego, La Jolla, California, United States of America
Matthew Budoff
Los Angeles Biomedical Research Institute, Torrance, California, United States of America
J. Jeffrey Carr
Departments of Radiologic Sciences, Internal Medicine-Cardiology, and Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America
Udo Hoffmann
Cardiac MR, PET, CT Program and the Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Jingzhong Ding
Department of Internal Medicine/Geriatrics, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Designed the study and drafted the manuscript: CSF YL. Performed the meta-analysis: CCW LAC. Performed the genetic correction analysis: C-TL. Performed the study-specific analyses: KL NH-C. Performed the functional studies: PC YZ. Performed the eQTL analyses: ADJ VE. Provided critical edits to the manuscript: Y-DIC KDT MA MB JIR JJC UH JD.