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Research Article

Extent, Causes, and Consequences of Small RNA Expression Variation in Human Adipose Tissue

  • Leopold Parts equal contributor,

    equal contributor Contributed equally to this work with: Leopold Parts, Åsa K. Hedman, Sarah Keildson

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom

    Current address: Donnelly Centre for Cellular and Biomolecular Research, Toronto, Canada

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  • Åsa K. Hedman equal contributor,

    equal contributor Contributed equally to this work with: Leopold Parts, Åsa K. Hedman, Sarah Keildson

    Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Sarah Keildson equal contributor,

    equal contributor Contributed equally to this work with: Leopold Parts, Åsa K. Hedman, Sarah Keildson

    Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Andrew J. Knights,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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  • Cei Abreu-Goodger,

    Affiliations: European Bioinformatics Institute, Hinxton, United Kingdom, National Laboratory of Genomics for Biodiversity (Langebio), Cinvestav, Irapuato, Mexico

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  • Martijn van de Bunt,

    Affiliations: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, United Kingdom

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  • José Afonso Guerra-Assunção,

    Affiliations: European Bioinformatics Institute, Hinxton, United Kingdom, PDBC, Instituto Gulbenkian de Ciência, Oeiras, Portugal

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  • Nenad Bartonicek,

    Affiliation: European Bioinformatics Institute, Hinxton, United Kingdom

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  • Stijn van Dongen,

    Affiliation: European Bioinformatics Institute, Hinxton, United Kingdom

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  • Reedik Mägi,

    Affiliations: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Estonian Genome Center, University of Tartu, Tartu, Estonia

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  • James Nisbet,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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  • Amy Barrett,

    Affiliation: Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, United Kingdom

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  • Mattias Rantalainen,

    Affiliations: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Department of Statistics, University of Oxford, Oxford, United Kingdom

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  • Alexandra C. Nica,

    Affiliation: Department of Genetic Medicine and Development and Institute of Genetics and Genomics in Geneva, University of Geneva Medical School, Geneva, Switzerland

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  • Michael A. Quail,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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  • Kerrin S. Small,

    Affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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  • Daniel Glass,

    Affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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  • Anton J. Enright,

    Affiliation: European Bioinformatics Institute, Hinxton, United Kingdom

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  • John Winn,

    Affiliation: Microsoft Research, Cambridge, United Kingdom

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  • MuTHER Consortium,
  • Panos Deloukas,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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  • Emmanouil T. Dermitzakis,

    Affiliation: Department of Genetic Medicine and Development and Institute of Genetics and Genomics in Geneva, University of Geneva Medical School, Geneva, Switzerland

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  • Mark I. McCarthy,

    Affiliations: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, United Kingdom

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  • Timothy D. Spector,

    Affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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  • Richard Durbin mail,

    rd@sanger.ac.uk (RD); celi@well.ox.ac.uk (CML)

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom

    These authors also contributed equally to this work.

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  • Cecilia M. Lindgren mail

    rd@sanger.ac.uk (RD); celi@well.ox.ac.uk (CML)

    Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

    These authors also contributed equally to this work.

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  • Published: May 10, 2012
  • DOI: 10.1371/journal.pgen.1002704

About the Authors

Leopold Parts, Andrew J. Knights, James Nisbet, Michael A. Quail, Panos Deloukas, Richard Durbin
Wellcome Trust Sanger Institute, Hinxton, United Kingdom
Åsa K. Hedman, Sarah Keildson, Martijn van de Bunt, Reedik Mägi, Mattias Rantalainen, Mark I. McCarthy, Cecilia M. Lindgren
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
Cei Abreu-Goodger, José Afonso Guerra-Assunção, Nenad Bartonicek, Stijn van Dongen, Anton J. Enright
European Bioinformatics Institute, Hinxton, United Kingdom
Cei Abreu-Goodger
National Laboratory of Genomics for Biodiversity (Langebio), Cinvestav, Irapuato, Mexico
Martijn van de Bunt, Amy Barrett, Mark I. McCarthy
Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, United Kingdom
José Afonso Guerra-Assunção
PDBC, Instituto Gulbenkian de Ciência, Oeiras, Portugal
Reedik Mägi
Estonian Genome Center, University of Tartu, Tartu, Estonia
Mattias Rantalainen
Department of Statistics, University of Oxford, Oxford, United Kingdom
Alexandra C. Nica, Emmanouil T. Dermitzakis
Department of Genetic Medicine and Development and Institute of Genetics and Genomics in Geneva, University of Geneva Medical School, Geneva, Switzerland
Kerrin S. Small, Daniel Glass, Timothy D. Spector
Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom
John Winn
Microsoft Research, Cambridge, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LP ÅKH CML RD. Performed the experiments: AJK JN AB MAQ. Contributed reagents/materials/analysis tools: JW AJE ACN KSS DG ETD PD MIM TDS. Wrote the paper: LP ÅKH SK RD CML. Analysed raw data: LP CA-G JAG-A NB. Analysed extent of variability and mRNA correlations: LP MvdB RM SvD CA-G. Analysed genotype and phenotype associations: SK ÅKH MR. Supervised study: RD CML.