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Research Article

KATNAL1 Regulation of Sertoli Cell Microtubule Dynamics Is Essential for Spermiogenesis and Male Fertility

  • Lee B. Smith mail,

    Lee.Smith@ed.ac.uk

    Affiliation: MRC Centre for Reproductive Health, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, United Kingdom

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  • Laura Milne,

    Affiliation: MRC Centre for Reproductive Health, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, United Kingdom

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  • Nancy Nelson,

    Affiliation: MRC Centre for Reproductive Health, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, United Kingdom

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  • Sharon Eddie,

    Affiliation: MRC Centre for Reproductive Health, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, United Kingdom

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  • Pamela Brown,

    Affiliation: MRC Centre for Reproductive Health, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, United Kingdom

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  • Nina Atanassova,

    Affiliation: Institute of Experimental Morphology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria

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  • Moira K. O'Bryan,

    Affiliation: The Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, Australia

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  • Liza O'Donnell,

    Affiliations: The Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, Australia, Prince Henry's Institute of Medical Research, Clayton, Victoria, Australia

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  • Danielle Rhodes,

    Affiliation: The Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, Australia

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  • Sara Wells,

    Affiliation: Mary Lyon Centre, Medical Research Council, Harwell Science and Innovation Campus, Harwell, Oxfordshire, United Kingdom

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  • Diane Napper,

    Affiliation: Mary Lyon Centre, Medical Research Council, Harwell Science and Innovation Campus, Harwell, Oxfordshire, United Kingdom

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  • Patrick Nolan,

    Affiliation: Mammalian Genetics Unit, Medical Research Council, Harwell Science and Innovation Campus, Harwell, Oxfordshire, United Kingdom

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  • Zuzanna Lalanne,

    Affiliation: Mammalian Genetics Unit, Medical Research Council, Harwell Science and Innovation Campus, Harwell, Oxfordshire, United Kingdom

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  • Michael Cheeseman,

    Affiliations: Mary Lyon Centre, Medical Research Council, Harwell Science and Innovation Campus, Harwell, Oxfordshire, United Kingdom, Mammalian Genetics Unit, Medical Research Council, Harwell Science and Innovation Campus, Harwell, Oxfordshire, United Kingdom

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  • Josephine Peters

    Affiliation: Mammalian Genetics Unit, Medical Research Council, Harwell Science and Innovation Campus, Harwell, Oxfordshire, United Kingdom

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  • Published: May 24, 2012
  • DOI: 10.1371/journal.pgen.1002697

About the Authors

Lee B. Smith, Laura Milne, Nancy Nelson, Sharon Eddie, Pamela Brown
MRC Centre for Reproductive Health, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, United Kingdom
Nina Atanassova
Institute of Experimental Morphology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria
Moira K. O'Bryan, Liza O'Donnell, Danielle Rhodes
The Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, Australia
Liza O'Donnell
Prince Henry's Institute of Medical Research, Clayton, Victoria, Australia
Sara Wells, Diane Napper, Michael Cheeseman
Mary Lyon Centre, Medical Research Council, Harwell Science and Innovation Campus, Harwell, Oxfordshire, United Kingdom
Patrick Nolan, Zuzanna Lalanne, Michael Cheeseman, Josephine Peters
Mammalian Genetics Unit, Medical Research Council, Harwell Science and Innovation Campus, Harwell, Oxfordshire, United Kingdom

Corresponding Author

Email: Lee.Smith@ed.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LBS MKO JP. Performed the experiments: LBS LM NN SE PB NA DR SW DN ZL MC. Analyzed the data: LBS LM MKO LO JP. Contributed reagents/materials/analysis tools: PN. Wrote the paper: LBS.