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Research Article

Genomic Hypomethylation in the Human Germline Associates with Selective Structural Mutability in the Human Genome

  • Jian Li,

    Affiliations: Bioinformatics Research Laboratory, Epigenome Center, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas, United States of America

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  • R. Alan Harris,

    Affiliations: Bioinformatics Research Laboratory, Epigenome Center, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Sau Wai Cheung,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Cristian Coarfa,

    Affiliations: Bioinformatics Research Laboratory, Epigenome Center, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Mira Jeong,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Margaret A. Goodell,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Lisa D. White,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Ankita Patel,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Sung-Hae Kang,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Chad Shaw,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • A. Craig Chinault,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Tomasz Gambin,

    Affiliation: Institute of Computer Science, Warsaw University of Technology, Warsaw, Poland

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  • Anna Gambin,

    Affiliation: Institute of Informatics, Warsaw University, Warsaw, Poland

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  • James R. Lupski,

    Affiliations: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America, Texas Children's Hospital, Houston, Texas, United States of America

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  • Aleksandar Milosavljevic mail

    amilosav@bcm.edu

    Affiliations: Bioinformatics Research Laboratory, Epigenome Center, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Published: May 17, 2012
  • DOI: 10.1371/journal.pgen.1002692

About the Authors

Jian Li, R. Alan Harris, Cristian Coarfa, Aleksandar Milosavljevic
Bioinformatics Research Laboratory, Epigenome Center, Baylor College of Medicine, Houston, Texas, United States of America
Jian Li, R. Alan Harris, Sau Wai Cheung, Cristian Coarfa, Mira Jeong, Margaret A. Goodell, Lisa D. White, Ankita Patel, Sung-Hae Kang, Chad Shaw, A. Craig Chinault, James R. Lupski, Aleksandar Milosavljevic
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
Jian Li, Aleksandar Milosavljevic
Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas, United States of America
Tomasz Gambin
Institute of Computer Science, Warsaw University of Technology, Warsaw, Poland
Anna Gambin
Institute of Informatics, Warsaw University, Warsaw, Poland
James R. Lupski
Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America
James R. Lupski
Texas Children's Hospital, Houston, Texas, United States of America

Corresponding Author

Email: amilosav@bcm.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JL AM. Performed the experiments: JL RAH SWC CC MJ LDW TG. Analyzed the data: JL RAH CC AM. Contributed reagents/materials/analysis tools: SWC MAG AP S-HK CS ACC AG. Wrote the paper: JL AM. Co-advised the study: JRL.