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Research Article

Sequence-Specific Targeting of Dosage Compensation in Drosophila Favors an Active Chromatin Context

  • Artyom A. Alekseyenko equal contributor,

    equal contributor Contributed equally to this work with: Artyom A. Alekseyenko, Joshua W. K. Ho, Shouyong Peng

    Affiliations: Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Joshua W. K. Ho equal contributor,

    equal contributor Contributed equally to this work with: Artyom A. Alekseyenko, Joshua W. K. Ho, Shouyong Peng

    Affiliations: Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Shouyong Peng equal contributor,

    equal contributor Contributed equally to this work with: Artyom A. Alekseyenko, Joshua W. K. Ho, Shouyong Peng

    Affiliations: Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Marnie Gelbart,

    Affiliations: Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Michael Y. Tolstorukov,

    Affiliations: Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Annette Plachetka,

    Affiliations: Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Peter V. Kharchenko,

    Affiliations: Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Youngsook L. Jung,

    Affiliations: Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Andrey A. Gorchakov,

    Affiliations: Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Erica Larschan,

    Affiliation: Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island, United States of America

    X
  • Tingting Gu,

    Affiliation: Department of Biology, Washington University in St. Louis, St. Louis, Missouri, United States of America

    X
  • Aki Minoda,

    Affiliations: Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America, Department of Genome Dynamics, Lawrence Berkeley National Lab, Berkeley, California, United States of America

    X
  • Nicole C. Riddle,

    Affiliation: Department of Biology, Washington University in St. Louis, St. Louis, Missouri, United States of America

    X
  • Yuri B. Schwartz,

    Affiliation: Department of Molecular Biology, Umeå University, Umeå, Sweden

    X
  • Sarah C. R. Elgin,

    Affiliation: Department of Biology, Washington University in St. Louis, St. Louis, Missouri, United States of America

    X
  • Gary H. Karpen,

    Affiliation: Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America

    X
  • Vincenzo Pirrotta,

    Affiliation: Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, United States of America

    X
  • Mitzi I. Kuroda mail,

    mkuroda@genetics.med.harvard.edu (MIK); peter_park@harvard.edu (PJP)

    Affiliations: Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Peter J. Park mail

    mkuroda@genetics.med.harvard.edu (MIK); peter_park@harvard.edu (PJP)

    Affiliations: Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Published: April 26, 2012
  • DOI: 10.1371/journal.pgen.1002646

About the Authors

Artyom A. Alekseyenko, Joshua W. K. Ho, Shouyong Peng, Marnie Gelbart, Michael Y. Tolstorukov, Annette Plachetka, Peter V. Kharchenko, Youngsook L. Jung, Andrey A. Gorchakov, Mitzi I. Kuroda, Peter J. Park
Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Artyom A. Alekseyenko, Marnie Gelbart, Annette Plachetka, Andrey A. Gorchakov, Mitzi I. Kuroda
Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
Joshua W. K. Ho, Shouyong Peng, Michael Y. Tolstorukov, Peter V. Kharchenko, Youngsook L. Jung, Peter J. Park
Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America
Erica Larschan
Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island, United States of America
Tingting Gu, Nicole C. Riddle, Sarah C. R. Elgin
Department of Biology, Washington University in St. Louis, St. Louis, Missouri, United States of America
Aki Minoda, Gary H. Karpen
Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America
Aki Minoda
Department of Genome Dynamics, Lawrence Berkeley National Lab, Berkeley, California, United States of America
Yuri B. Schwartz
Department of Molecular Biology, Umeå University, Umeå, Sweden
Vincenzo Pirrotta
Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GHK SCRE VP PJP MIK. Performed the experiments: AAA MG AP AAG EL TG AM NCR YBS. Analyzed the data: JWKH SP MYT PVK YLJ PJP. Wrote the paper: JWKH AAA PJP MIK.