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Research Article

Patterns of Cis Regulatory Variation in Diverse Human Populations

  • Barbara E. Stranger equal contributor,

    equal contributor Contributed equally to this work with: Barbara E. Stranger, Stephen B. Montgomery, Antigone S. Dimas

    Affiliations: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom, Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Stephen B. Montgomery equal contributor,

    equal contributor Contributed equally to this work with: Barbara E. Stranger, Stephen B. Montgomery, Antigone S. Dimas

    Affiliations: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom, Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland, Institute of Genetics and Genomics in Geneva (iGE3), Geneva, Switzerland

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  • Antigone S. Dimas equal contributor,

    equal contributor Contributed equally to this work with: Barbara E. Stranger, Stephen B. Montgomery, Antigone S. Dimas

    Affiliations: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom, Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland, Institute of Genetics and Genomics in Geneva (iGE3), Geneva, Switzerland, Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom, Max Planck Institute Intelligent Systems and Max Planck Institute for Developmental Biology, Tübingen, Germany

    X
  • Leopold Parts,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Oliver Stegle,

    Affiliation: Max Planck Institute Intelligent Systems and Max Planck Institute for Developmental Biology, Tübingen, Germany

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  • Catherine E. Ingle,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Magda Sekowska,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • George Davey Smith,

    Affiliation: MRC CAiTE centre, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

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  • David Evans,

    Affiliation: MRC CAiTE centre, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

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  • Maria Gutierrez-Arcelus,

    Affiliations: Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland, Institute of Genetics and Genomics in Geneva (iGE3), Geneva, Switzerland

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  • Alkes Price,

    Affiliations: Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Epidemiology and Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Towfique Raj,

    Affiliations: Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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  • James Nisbett,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Alexandra C. Nica,

    Affiliations: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom, Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland, Institute of Genetics and Genomics in Geneva (iGE3), Geneva, Switzerland

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  • Claude Beazley,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Richard Durbin,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Panos Deloukas,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Emmanouil T. Dermitzakis mail

    emmanouil.dermitzakis@unige.ch

    Affiliations: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom, Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland, Institute of Genetics and Genomics in Geneva (iGE3), Geneva, Switzerland

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  • Published: April 19, 2012
  • DOI: 10.1371/journal.pgen.1002639

About the Authors

Barbara E. Stranger, Stephen B. Montgomery, Antigone S. Dimas, Leopold Parts, Catherine E. Ingle, Magda Sekowska, James Nisbett, Alexandra C. Nica, Claude Beazley, Richard Durbin, Panos Deloukas, Emmanouil T. Dermitzakis
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
Barbara E. Stranger, Towfique Raj
Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
Barbara E. Stranger, Alkes Price, Towfique Raj
Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Barbara E. Stranger
Harvard Medical School, Boston, Massachusetts, United States of America
Stephen B. Montgomery, Antigone S. Dimas, Maria Gutierrez-Arcelus, Alexandra C. Nica, Emmanouil T. Dermitzakis
Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland
Stephen B. Montgomery, Antigone S. Dimas, Maria Gutierrez-Arcelus, Alexandra C. Nica, Emmanouil T. Dermitzakis
Institute of Genetics and Genomics in Geneva (iGE3), Geneva, Switzerland
Antigone S. Dimas
Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom
Antigone S. Dimas, Oliver Stegle
Max Planck Institute Intelligent Systems and Max Planck Institute for Developmental Biology, Tübingen, Germany
George Davey Smith, David Evans
MRC CAiTE centre, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
Alkes Price
Department of Epidemiology and Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America
Towfique Raj
Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Corresponding Author

Email: emmanouil.dermitzakis@unige.ch

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BES SBM ASD PD ETD. Performed the experiments: CEI MS JN. Analyzed the data: BES SBM ASD LP OS ACN CB TR MG-A. Contributed reagents/materials/analysis tools: GDS DE RD AP. Wrote the paper: BES SBM ASD ETD.