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Research Article

Hypoxia Disruption of Vertebrate CNS Pathfinding through EphrinB2 Is Rescued by Magnesium

  • Tamara J. Stevenson,

    Affiliation: Division of Pediatric Neurology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

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  • Tony Trinh,

    Affiliation: University of Utah School of Medicine, Salt Lake City, Utah, United States of America

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  • Cory Kogelschatz,

    Affiliation: University of Utah School of Medicine, Salt Lake City, Utah, United States of America

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  • Esther Fujimoto,

    Affiliations: Division of Pediatric Neurology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America, Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

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  • Mark E. Lush,

    Affiliation: Stowers Institute for Medical Research, Kansas City, Missouri, United States of America

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  • Tatjana Piotrowski,

    Affiliation: Stowers Institute for Medical Research, Kansas City, Missouri, United States of America

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  • Cameron J. Brimley,

    Affiliation: University of Utah School of Medicine, Salt Lake City, Utah, United States of America

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  • Joshua L. Bonkowsky mail

    joshua.bonkowsky@hsc.utah.edu

    Affiliations: Division of Pediatric Neurology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America, Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

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  • Published: April 12, 2012
  • DOI: 10.1371/journal.pgen.1002638

About the Authors

Tamara J. Stevenson, Esther Fujimoto, Joshua L. Bonkowsky
Division of Pediatric Neurology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
Tony Trinh, Cory Kogelschatz, Cameron J. Brimley
University of Utah School of Medicine, Salt Lake City, Utah, United States of America
Esther Fujimoto, Joshua L. Bonkowsky
Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
Mark E. Lush, Tatjana Piotrowski
Stowers Institute for Medical Research, Kansas City, Missouri, United States of America

Corresponding Author

Email: joshua.bonkowsky@hsc.utah.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TJS TT CK JLB. Performed the experiments: TJS TT CK EF CJB JLB. Analyzed the data: TJS TT CK JLB. Contributed reagents/materials/analysis tools: CJB MEL TP EF. Wrote the paper: TJS JLB.