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Research Article

DNA Resection at Chromosome Breaks Promotes Genome Stability by Constraining Non-Allelic Homologous Recombination

  • Frederick J. Tan equal contributor,

    equal contributor Contributed equally to this work with: Frederick J. Tan, Margaret L. Hoang

    Affiliations: Howard Hughes Medical Institute and Department of Embryology, Carnegie Institution, Baltimore, Maryland, United States of America, Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America

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  • Margaret L. Hoang equal contributor,

    equal contributor Contributed equally to this work with: Frederick J. Tan, Margaret L. Hoang

    Affiliations: Howard Hughes Medical Institute and Department of Embryology, Carnegie Institution, Baltimore, Maryland, United States of America, Department of Biology, Johns Hopkins University, Baltimore, Maryland, United States of America

    Current address: Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins Medical Institute, Baltimore, Maryland, United States of America

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  • Douglas Koshland mail

    koshland@berkeley.edu

    Affiliations: Howard Hughes Medical Institute and Department of Embryology, Carnegie Institution, Baltimore, Maryland, United States of America, Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America

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  • Published: March 29, 2012
  • DOI: 10.1371/journal.pgen.1002633

About the Authors

Frederick J. Tan, Margaret L. Hoang, Douglas Koshland
Howard Hughes Medical Institute and Department of Embryology, Carnegie Institution, Baltimore, Maryland, United States of America
Frederick J. Tan, Douglas Koshland
Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America
Margaret L. Hoang
Department of Biology, Johns Hopkins University, Baltimore, Maryland, United States of America

Corresponding Author

Email: koshland@berkeley.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FJT MLH DK. Performed the experiments: FJT MLH. Analyzed the data: FJT MLH DK. Contributed reagents/materials/analysis tools: FJT MLH. Wrote the paper: FJT MLH DK.