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Research Article

Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population

  • Jordana T. Bell equal contributor mail,

    equal contributor Contributed equally to this work with: Jordana T. Bell, Pei-Chien Tsai

    jordana.bell@kcl.ac.uk (JTB); tim.spector@kcl.ac.uk (TDS); panos@sanger.ac.uk (PD)

    Affiliations: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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  • Pei-Chien Tsai equal contributor,

    equal contributor Contributed equally to this work with: Jordana T. Bell, Pei-Chien Tsai

    Affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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  • Tsun-Po Yang,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Ruth Pidsley,

    Affiliation: MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, United Kingdom

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  • James Nisbet,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Daniel Glass,

    Affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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  • Massimo Mangino,

    Affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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  • Guangju Zhai,

    Affiliations: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada

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  • Feng Zhang,

    Affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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  • Ana Valdes,

    Affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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  • So-Youn Shin,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Emma L. Dempster,

    Affiliation: MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, United Kingdom

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  • Robin M. Murray,

    Affiliation: Department of Psychosis Studies, Institute of Psychiatry, King's College London, London, United Kingdom

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  • Elin Grundberg,

    Affiliations: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Asa K. Hedman,

    Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Alexandra Nica,

    Affiliation: Department of Genetic Medicine and Development, University of Geneva, Geneva, Switzerland

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  • Kerrin S. Small,

    Affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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  • The MuTHER Consortium,

    ‡ Membership of the MuTHER Consortium is provided in the Acknowledgments.

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  • Emmanouil T. Dermitzakis,

    Affiliation: Department of Genetic Medicine and Development, University of Geneva, Geneva, Switzerland

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  • Mark I. McCarthy,

    Affiliations: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom, Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Oxford, United Kingdom

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  • Jonathan Mill,

    Affiliation: MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, United Kingdom

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  • Tim D. Spector mail,

    jordana.bell@kcl.ac.uk (JTB); tim.spector@kcl.ac.uk (TDS); panos@sanger.ac.uk (PD)

    Affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

    These authors also contributed equally to this work.

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  • Panos Deloukas mail

    jordana.bell@kcl.ac.uk (JTB); tim.spector@kcl.ac.uk (TDS); panos@sanger.ac.uk (PD)

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

    These authors also contributed equally to this work.

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  • Published: April 19, 2012
  • DOI: 10.1371/journal.pgen.1002629

About the Authors

Jordana T. Bell, Asa K. Hedman, Mark I. McCarthy
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
Jordana T. Bell, Pei-Chien Tsai, Daniel Glass, Massimo Mangino, Guangju Zhai, Feng Zhang, Ana Valdes, Elin Grundberg, Kerrin S. Small, Tim D. Spector
Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom
Tsun-Po Yang, James Nisbet, So-Youn Shin, Elin Grundberg, Panos Deloukas
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
Ruth Pidsley, Emma L. Dempster, Jonathan Mill
MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, United Kingdom
Guangju Zhai
Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada
Robin M. Murray
Department of Psychosis Studies, Institute of Psychiatry, King's College London, London, United Kingdom
Alexandra Nica, Emmanouil T. Dermitzakis
Department of Genetic Medicine and Development, University of Geneva, Geneva, Switzerland
Mark I. McCarthy
Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom
Mark I. McCarthy
Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Oxford, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JTB TDS. Performed the experiments: JN. Analyzed the data: P-CT JTB. Contributed reagents/materials/analysis tools: T-PY RP DG MM GZ FZ AV S-YS ELD RMM EG AKH AN KSS ETD MIM JM TDS PD. Wrote the paper: JTB P-CT TDS PD.