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Research Article

SMG-1 and mTORC1 Act Antagonistically to Regulate Response to Injury and Growth in Planarians

  • Cristina González-Estévez mail,

    aziz.aboobaker@nottingham.ac.uk (AAA); cristina.gonzalez.estevez@gmail.com (CG-E)

    Affiliation: Centre for Genetics and Genomics, University of Nottingham, Queens Medical Centre, Nottingham, United Kingdom

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  • Daniel A. Felix,

    Affiliation: Centre for Genetics and Genomics, University of Nottingham, Queens Medical Centre, Nottingham, United Kingdom

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  • Matthew D. Smith,

    Affiliation: Centre for Genetics and Genomics, University of Nottingham, Queens Medical Centre, Nottingham, United Kingdom

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  • Jordi Paps,

    Affiliation: Department of Zoology, University of Oxford, Oxford, United Kingdom

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  • Simon J. Morley,

    Affiliation: Department of Biochemistry, School of Life Sciences, University of Sussex, Brighton, United Kingdom

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  • Victoria James,

    Affiliation: School of Biomedical Sciences, University of Nottingham Medical School, Nottingham, United Kingdom

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  • Tyson V. Sharp,

    Affiliation: School of Biomedical Sciences, University of Nottingham Medical School, Nottingham, United Kingdom

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  • A. Aziz Aboobaker mail

    aziz.aboobaker@nottingham.ac.uk (AAA); cristina.gonzalez.estevez@gmail.com (CG-E)

    Affiliation: Centre for Genetics and Genomics, University of Nottingham, Queens Medical Centre, Nottingham, United Kingdom

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  • Published: March 29, 2012
  • DOI: 10.1371/journal.pgen.1002619

About the Authors

Cristina González-Estévez, Daniel A. Felix, Matthew D. Smith, A. Aziz Aboobaker
Centre for Genetics and Genomics, University of Nottingham, Queens Medical Centre, Nottingham, United Kingdom
Jordi Paps
Department of Zoology, University of Oxford, Oxford, United Kingdom
Simon J. Morley
Department of Biochemistry, School of Life Sciences, University of Sussex, Brighton, United Kingdom
Victoria James, Tyson V. Sharp
School of Biomedical Sciences, University of Nottingham Medical School, Nottingham, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CG-E AAA. Performed the experiments: CG-E MDS DAF SJM JP. Analyzed the data: CG-E AAA. Contributed reagents/materials/analysis tools: CG-E JP TVS VJ AAA. Wrote the paper: CG-E AAA.