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Research Article

Probing the Informational and Regulatory Plasticity of a Transcription Factor DNA–Binding Domain

  • Ryan K. Shultzaberger,

    Affiliation: Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America

    Current address: Kavli Institute for Brain and Mind, University of California San Diego, La Jolla, California, United States of America

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  • Sebastian J. Maerkl,

    Affiliation: School of Engineering, Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne, Switzerland

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  • Jack F. Kirsch,

    Affiliation: Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America

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  • Michael B. Eisen mail

    mbeisen@berkeley.edu

    Affiliations: Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America, Department of Genome Sciences, Genomic Division, Ernest Orlando Lawrence Berkeley National Lab, Berkeley, California, United States of America, Howard Hughes Medical Institute, University of California Berkeley, Berkeley, California, United States of America

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  • Published: March 29, 2012
  • DOI: 10.1371/journal.pgen.1002614

About the Authors

Ryan K. Shultzaberger, Jack F. Kirsch, Michael B. Eisen
Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America
Sebastian J. Maerkl
School of Engineering, Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne, Switzerland
Michael B. Eisen
Department of Genome Sciences, Genomic Division, Ernest Orlando Lawrence Berkeley National Lab, Berkeley, California, United States of America
Michael B. Eisen
Howard Hughes Medical Institute, University of California Berkeley, Berkeley, California, United States of America

Corresponding Author

Email: mbeisen@berkeley.edu

Competing Interests

MBE is a co-founder and member of the board of directors of PLoS.

Author Contributions

Conceived and designed the experiments: RKS SJM MBE JFK. Performed the experiments: RKS SJM. Analyzed the data: RKS SJM. Contributed reagents/materials/analysis tools: RKS SJM. Wrote the paper: RKS SJM JFK MBE.