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Research Article

Common Genetic Determinants of Intraocular Pressure and Primary Open-Angle Glaucoma

  • Leonieke M. E. van Koolwijk equal contributor,

    equal contributor Contributed equally to this work with: Leonieke M. E. van Koolwijk, Wishal D. Ramdas

    Affiliations: Glaucoma Service, The Rotterdam Eye Hospital, Rotterdam, The Netherlands, Department of Epidemiology, The Erasmus University Medical Center, Rotterdam, The Netherlands

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  • Wishal D. Ramdas equal contributor,

    equal contributor Contributed equally to this work with: Leonieke M. E. van Koolwijk, Wishal D. Ramdas

    Affiliations: Department of Epidemiology, The Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Ophthalmology, The Erasmus University Medical Center, Rotterdam, The Netherlands

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  • M. Kamran Ikram,

    Affiliations: Department of Epidemiology, The Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Ophthalmology, The Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Neurology, The Erasmus University Medical Center, Rotterdam, The Netherlands

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  • Nomdo M. Jansonius,

    Affiliations: Department of Epidemiology, The Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Ophthalmology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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  • Francesca Pasutto,

    Affiliation: Institute of Human Genetics, University Erlangen-Nuremberg, Erlangen, Germany

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  • Pirro G. Hysi,

    Affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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  • Stuart Macgregor,

    Affiliation: Queensland Institute of Medical Research, Brisbane, Australia

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  • Sarah F. Janssen,

    Affiliation: Department of Molecular Ophthalmogenetics, The Netherlands Institute for Neuroscience (NIN), Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, The Netherlands

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  • Alex W. Hewitt,

    Affiliation: Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia

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  • Ananth C. Viswanathan,

    Affiliation: NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom

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  • Jacoline B. ten Brink,

    Affiliation: Department of Molecular Ophthalmogenetics, The Netherlands Institute for Neuroscience (NIN), Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, The Netherlands

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  • S. Mohsen Hosseini,

    Affiliation: Program in Genetics and Genome Biology, Hospital for Sick Children, Toronto, Canada

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  • Najaf Amin,

    Affiliation: Department of Epidemiology, The Erasmus University Medical Center, Rotterdam, The Netherlands

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  • Dominiek D. G. Despriet,

    Affiliations: Department of Epidemiology, The Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Ophthalmology, The Erasmus University Medical Center, Rotterdam, The Netherlands

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  • Jacqueline J. M. Willemse-Assink,

    Affiliation: Department of Ophthalmology, Amphia Hospital, Breda, The Netherlands

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  • Rogier Kramer,

    Affiliation: Department of Ophthalmology, Franciscus Hospital, Roosendaal, The Netherlands

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  • Fernando Rivadeneira,

    Affiliations: Department of Epidemiology, The Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Internal Medicine, The Erasmus University Medical Center, Rotterdam, The Netherlands

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  • Maksim Struchalin,

    Affiliation: Department of Epidemiology, The Erasmus University Medical Center, Rotterdam, The Netherlands

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  • Yurii S. Aulchenko,

    Affiliation: Department of Epidemiology, The Erasmus University Medical Center, Rotterdam, The Netherlands

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  • Nicole Weisschuh,

    Affiliation: Molecular Genetics Laboratory, University Eye Hospital, Tübingen, Germany

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  • Matthias Zenkel,

    Affiliation: Department of Ophthalmology, University of Erlangen-Nuremberg, Erlangen, Germany

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  • Christian Y. Mardin,

    Affiliation: Department of Ophthalmology, University of Erlangen-Nuremberg, Erlangen, Germany

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  • Eugen Gramer,

    Affiliation: University Eye Hospital, Würzburg, Germany

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  • Ulrich Welge-Lüssen,

    Affiliation: Department of Ophthalmology, Friedrich-Alexander University, Erlangen, Germany

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  • Grant W. Montgomery,

    Affiliation: Queensland Institute of Medical Research, Brisbane, Australia

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  • Francis Carbonaro,

    Affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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  • Terri L. Young,

    Affiliation: Center for Human Genetics, Duke University, Durham, North Carolina, United States of America

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  • The DCCT/EDIC Research Group,
  • Céline Bellenguez,

    Affiliation: Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom

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  • Peter McGuffin,

    Affiliation: MRC Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College, London, United Kingdom

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  • Paul J. Foster,

    Affiliation: NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom

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  • Fotis Topouzis,

    Affiliation: Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece

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  • Paul Mitchell,

    Affiliation: Centre for Vision Research, University of Sydney, Sydney, Australia

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  • Jie Jin Wang,

    Affiliation: Centre for Vision Research, University of Sydney, Sydney, Australia

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  • Tien Y. Wong,

    Affiliations: Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia, Singapore National Eye Centre and Singapore Eye Research Institute, Singapore, Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

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  • Monika A. Czudowska,

    Affiliations: Department of Epidemiology, The Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Ophthalmology, The Erasmus University Medical Center, Rotterdam, The Netherlands

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  • Albert Hofman,

    Affiliation: Department of Epidemiology, The Erasmus University Medical Center, Rotterdam, The Netherlands

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  • Andre G. Uitterlinden,

    Affiliations: Department of Epidemiology, The Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Internal Medicine, The Erasmus University Medical Center, Rotterdam, The Netherlands

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  • Roger C. W. Wolfs,

    Affiliations: Department of Epidemiology, The Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Ophthalmology, The Erasmus University Medical Center, Rotterdam, The Netherlands

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  • Paulus T. V. M. de Jong,

    Affiliations: Department of Molecular Ophthalmogenetics, The Netherlands Institute for Neuroscience (NIN), Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, The Netherlands, Department of Ophthalmology, Academic Medical Center, Amsterdam, The Netherlands

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  • Ben A. Oostra,

    Affiliation: Department of Clinical Genetics, The Erasmus University Medical Center, Rotterdam, The Netherlands

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  • Andrew D. Paterson,

    Affiliations: Program in Genetics and Genome Biology, Hospital for Sick Children, Toronto, Canada, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada

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  • Wellcome Trust Case Control Consortium 2,

    Membership of WTCCC2 is provided in the Acknowledgments.

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  • David A. Mackey,

    Affiliation: Lions Eye Institute, University of Western Australia, Centre for Ophthalmology and Visual Science, Perth, Australia

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  • Arthur A. B. Bergen,

    Affiliations: Department of Molecular Ophthalmogenetics, The Netherlands Institute for Neuroscience (NIN), Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, The Netherlands, Department of Ophthalmology, Academic Medical Center, Amsterdam, The Netherlands, Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands

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  • André Reis,

    Affiliation: Institute of Human Genetics, University Erlangen-Nuremberg, Erlangen, Germany

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  • Christopher J. Hammond,

    Affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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  • Johannes R. Vingerling,

    Affiliations: Department of Epidemiology, The Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Ophthalmology, The Erasmus University Medical Center, Rotterdam, The Netherlands

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  • Hans G. Lemij,

    Affiliation: Glaucoma Service, The Rotterdam Eye Hospital, Rotterdam, The Netherlands

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  • Caroline C. W. Klaver,

    Affiliations: Department of Epidemiology, The Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Ophthalmology, The Erasmus University Medical Center, Rotterdam, The Netherlands

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  • Cornelia M. van Duijn mail

    c.vanduijn@erasmusmc.nl

    Affiliation: Department of Epidemiology, The Erasmus University Medical Center, Rotterdam, The Netherlands

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  • Published: May 03, 2012
  • DOI: 10.1371/journal.pgen.1002611

About the Authors

Leonieke M. E. van Koolwijk, Hans G. Lemij
Glaucoma Service, The Rotterdam Eye Hospital, Rotterdam, The Netherlands
Leonieke M. E. van Koolwijk, Wishal D. Ramdas, M. Kamran Ikram, Nomdo M. Jansonius, Najaf Amin, Dominiek D. G. Despriet, Fernando Rivadeneira, Maksim Struchalin, Yurii S. Aulchenko, Monika A. Czudowska, Albert Hofman, Andre G. Uitterlinden, Roger C. W. Wolfs, Johannes R. Vingerling, Caroline C. W. Klaver, Cornelia M. van Duijn
Department of Epidemiology, The Erasmus University Medical Center, Rotterdam, The Netherlands
Wishal D. Ramdas, M. Kamran Ikram, Dominiek D. G. Despriet, Monika A. Czudowska, Roger C. W. Wolfs, Johannes R. Vingerling, Caroline C. W. Klaver
Department of Ophthalmology, The Erasmus University Medical Center, Rotterdam, The Netherlands
M. Kamran Ikram
Department of Neurology, The Erasmus University Medical Center, Rotterdam, The Netherlands
Nomdo M. Jansonius
Department of Ophthalmology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Francesca Pasutto, André Reis
Institute of Human Genetics, University Erlangen-Nuremberg, Erlangen, Germany
Pirro G. Hysi, Francis Carbonaro, Christopher J. Hammond
Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom
Stuart Macgregor, Grant W. Montgomery
Queensland Institute of Medical Research, Brisbane, Australia
Sarah F. Janssen, Jacoline B. ten Brink, Paulus T. V. M. de Jong, Arthur A. B. Bergen
Department of Molecular Ophthalmogenetics, The Netherlands Institute for Neuroscience (NIN), Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, The Netherlands
Alex W. Hewitt, Tien Y. Wong
Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia
Ananth C. Viswanathan, Paul J. Foster
NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom
S. Mohsen Hosseini, Andrew D. Paterson
Program in Genetics and Genome Biology, Hospital for Sick Children, Toronto, Canada
Jacqueline J. M. Willemse-Assink
Department of Ophthalmology, Amphia Hospital, Breda, The Netherlands
Rogier Kramer
Department of Ophthalmology, Franciscus Hospital, Roosendaal, The Netherlands
Fernando Rivadeneira, Andre G. Uitterlinden
Department of Internal Medicine, The Erasmus University Medical Center, Rotterdam, The Netherlands
Nicole Weisschuh
Molecular Genetics Laboratory, University Eye Hospital, Tübingen, Germany
Matthias Zenkel, Christian Y. Mardin
Department of Ophthalmology, University of Erlangen-Nuremberg, Erlangen, Germany
Eugen Gramer
University Eye Hospital, Würzburg, Germany
Ulrich Welge-Lüssen
Department of Ophthalmology, Friedrich-Alexander University, Erlangen, Germany
Terri L. Young
Center for Human Genetics, Duke University, Durham, North Carolina, United States of America
Céline Bellenguez
Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom
Peter McGuffin
MRC Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College, London, United Kingdom
Fotis Topouzis
Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece
Paul Mitchell, Jie Jin Wang
Centre for Vision Research, University of Sydney, Sydney, Australia
Tien Y. Wong
Singapore National Eye Centre and Singapore Eye Research Institute, Singapore, Singapore
Tien Y. Wong
Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Paulus T. V. M. de Jong, Arthur A. B. Bergen
Department of Ophthalmology, Academic Medical Center, Amsterdam, The Netherlands
Ben A. Oostra
Department of Clinical Genetics, The Erasmus University Medical Center, Rotterdam, The Netherlands
Andrew D. Paterson
Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
David A. Mackey
Lions Eye Institute, University of Western Australia, Centre for Ophthalmology and Visual Science, Perth, Australia
Arthur A. B. Bergen
Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands

Corresponding Author

Email: c.vanduijn@erasmusmc.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LMEvK NMJ FR AH AGU RCWW PTVMdJ BAO JRV HGL CCWK CMvD. Performed the experiments: LMEvK WDR MKI DDGD JJMW-A RK MAC SFJ NA MS YSA AABB. Analyzed the data: LMEvK WDR CMvD. Contributed reagents/materials/analysis tools: PGH FC TLY CJH SM AWH GWM TLY DAM SMH ADP ACV CB PMcG PJF FT PM JJW TYW SFJ JBtB PTVMdJ AABB FP NW MZ CYM EG UW-L AR. Wrote the paper: LMEvK WDR CMvD. Contributed to the final version of the manuscript: all authors.