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Research Article

Gene Reactivation by 5-Aza-2′-Deoxycytidine–Induced Demethylation Requires SRCAP–Mediated H2A.Z Insertion to Establish Nucleosome Depleted Regions

  • Xiaojing Yang,

    Affiliation: Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Houtan Noushmehr,

    Affiliation: USC Epigenome Center, University of Southern California, Los Angeles, California, United States of America

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  • Han Han,

    Affiliations: Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America, Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, United States of America

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  • Claudia Andreu-Vieyra,

    Affiliation: Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Gangning Liang,

    Affiliation: Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Peter A. Jones mail

    pjones@med.usc.edu

    Affiliation: Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Published: March 29, 2012
  • DOI: 10.1371/journal.pgen.1002604

About the Authors

Xiaojing Yang, Han Han, Claudia Andreu-Vieyra, Gangning Liang, Peter A. Jones
Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
Houtan Noushmehr
USC Epigenome Center, University of Southern California, Los Angeles, California, United States of America
Han Han
Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, United States of America

Corresponding Author

Email: pjones@med.usc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: XY GL PAJ. Performed the experiments: XY HH GL. Analyzed the data: XY HN. Contributed reagents/materials/analysis tools: HN. Wrote the paper: XY HN HH CA-V PAJ.